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在使用低能电子束治疗眼部淋巴瘤时,填充物和晶状体屏蔽的剂量学效应。

Dosimetric effects of bolus and lens shielding in treating ocular lymphomas with low-energy electrons.

作者信息

Young Lori, Wootton Landon S, Kalet Alan M, Gopan Olga, Yang Fei, Day Samuel, Banitt Michael, Liao Jay J

机构信息

Department of Radiation Oncology, University of Washington, Seattle, WA 98195.

Department of Radiation Oncology, University of Washington, Seattle, WA 98195.

出版信息

Med Dosim. 2019;44(1):35-42. doi: 10.1016/j.meddos.2018.01.005. Epub 2018 Apr 23.

Abstract

Radiation therapy is an effective treatment for primary orbital lymphomas. Lens shielding with electrons can reduce the risk of high-grade cataracts in patients undergoing treatment for superficial tumors. This work evaluates the dosimetric effects of a suspended eye shield, placement of bolus, and varying electron energies. Film (GafChromic EBT3) dosimetry and relative output factors were measured for 6, 8, and 10 MeV electron energies. A customized 5-cm diameter circle electron orbital cutout was constructed for a 6 × 6-cm applicator with a suspended lens shield (8-mm diameter Cerrobend cylinder, 2.2-cm length). Point doses were measured using a scanning electron diode in a solid water phantom at depths representative of the anterior and posterior lens. Depth dose profiles were compared for 0-mm, 3-mm, and 5-mm bolus thicknesses. At 5 mm (the approximate distance of the anterior lens from the surface of the cornea), the percent depth dose under the suspended lens shield was reduced to 15%, 15%, and 14% for electron energies 6, 8, and 10 MeV, respectively. Applying bolus reduced the benefit of lens shielding by increasing the estimated doses under the block to 27% for 3-mm and 44% for 5-mm bolus for a 6 MeV incident electron beam. This effect is minimized with 8 MeV electron beams where the corresponding values were 15.5% and 18% for 3-mm and 5-mm bolus. Introduction of a 7-mm hole in 5-mm bolus to stabilize eye motion during treatment altered lens doses by about 1%. Careful selection of electron energy and consideration of bolus effects are needed to account for electron scatter under a lens shield.

摘要

放射治疗是原发性眼眶淋巴瘤的一种有效治疗方法。对于接受浅表肿瘤治疗的患者,使用电子线进行晶状体屏蔽可降低发生高度白内障的风险。本研究评估了悬吊式眼罩、填充物放置以及不同电子能量的剂量学效应。针对6、8和10 MeV的电子能量测量了胶片(GafChromic EBT3)剂量学和相对输出因子。为一个6×6 cm的施源器构建了一个定制的直径5 cm的圆形电子眼眶限光筒,并配备悬吊式晶状体屏蔽(直径8 mm的铈镓合金圆柱体,长度2.2 cm)。在固体水模体中,使用扫描电子二极管在代表晶状体前后部的深度处测量点剂量。比较了0 mm、3 mm和5 mm填充物厚度下的深度剂量分布。在5 mm(晶状体前部距角膜表面的近似距离)处,对于6、8和10 MeV的电子能量,悬吊式晶状体屏蔽下的百分深度剂量分别降至15%、15%和14%。对于6 MeV的入射电子束,应用填充物会增加铅挡块下的估计剂量,3 mm填充物时增至27%,5 mm填充物时增至44%,从而降低了晶状体屏蔽的益处。对于8 MeV的电子束,这种效应最小化,3 mm和5 mm填充物时相应的值分别为15.5%和18%。在5 mm填充物中引入一个7 mm的孔以在治疗期间稳定眼球运动,使晶状体剂量改变了约1%。需要仔细选择电子能量并考虑填充物效应,以考虑晶状体屏蔽下的电子散射。

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