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主动脉弓重建:杂交去分支手术是一个好的选择吗?

Aortic Arch Reconstruction: Are Hybrid Debranching Procedures a Good Choice?

作者信息

Papakonstantinou Nikolaos A, Antonopoulos Constantine N, Baikoussis Nikolaos G, Kakisis Ioannis, Geroulakos Georgios

机构信息

Cardiovascular and Thoracic Surgery Department, General Hospital of Athens "Evangelismos", Athens, Greece.

Cardiovascular and Thoracic Surgery Department, General Hospital of Athens "Evangelismos", Athens, Greece.

出版信息

Heart Lung Circ. 2018 Nov;27(11):1335-1349. doi: 10.1016/j.hlc.2018.03.016. Epub 2018 Mar 30.

Abstract

INTRODUCTION

Conventional open total arch replacement is the treatment of choice for surgical aortic arch pathologies. However, it is an invasive procedure, requiring cardiopulmonary bypass and deep hypothermic circulatory arrest leading to significant morbidity and mortality rates. Hybrid aortic arch debranching procedures without (type I) or with (type II) ascending aorta replacement seek to limit operative, bypass, and circulatory arrest times by making the arch repair procedure simpler and shorter.

MATERIAL AND METHODS

A meta-analysis and detailed review of the literature published from January 2013 until December 2016, concerning hybrid aortic arch debranching procedures was conducted and data for morbidity and mortality rates were extracted.

RESULTS

As far as type I hybrid aortic arch reconstruction is concerned, among the 122 patients included, the pooled endoleak rate was 10.78% (95%CI=1.94-23.40), 30-day or in-hospital mortality was 3.89% (95%CI=0.324-9.78), stroke rate was 3.79% (95%CI=0.25-9.77) and weighted permanent paraplegia rate was 2.4%. In terms of type II hybrid approach, among 40 patients, endoleak rate was 12.5%, 30-day or in-hospital mortality rate was 5.3%, stroke rate was 2.5%, no permanent paraplegia was noticed and late mortality rate was 12.5%.

CONCLUSIONS

Hybrid aortic arch debranching procedures are a safe alternative to open repair with acceptable short- and mid-term results. They extend the envelope of intervention in aortic arch pathologies, particularly in high-risk patients who are suboptimal candidates for open surgery.

摘要

引言

传统的开放性全主动脉弓置换术是治疗主动脉弓病变的首选方法。然而,这是一种侵入性手术,需要体外循环和深低温停循环,导致较高的发病率和死亡率。不进行升主动脉置换(I型)或进行升主动脉置换(II型)的杂交主动脉弓去分支手术旨在通过简化和缩短主动脉弓修复手术来限制手术、体外循环和停循环时间。

材料与方法

对2013年1月至2016年12月发表的有关杂交主动脉弓去分支手术的文献进行荟萃分析和详细综述,并提取发病率和死亡率数据。

结果

就I型杂交主动脉弓重建而言,纳入的122例患者中,内漏合并发生率为10.78%(95%CI=1.94-23.40),30天或住院死亡率为3.89%(95%CI=0.324-9.78),卒中发生率为3.79%(95%CI=0.25-9.77),加权永久性截瘫发生率为2.4%。对于II型杂交手术方式,40例患者中,内漏发生率为12.5%,30天或住院死亡率为5.3%,卒中发生率为2.5%,未发现永久性截瘫,晚期死亡率为12.5%。

结论

杂交主动脉弓去分支手术是开放性修复的一种安全替代方法,具有可接受的短期和中期结果。它们扩大了主动脉弓病变的干预范围,特别是对于那些不适合开放性手术的高危患者。

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