National Institute of Public Health-National Institute of Hygiene, Laboratory of Biologically Active Compounds, Warsaw, Poland.
Siedlce University, Faculty of Science, Siedlce, Poland.
J Antibiot (Tokyo). 2018 Aug;71(8):757-761. doi: 10.1038/s41429-018-0059-6. Epub 2018 Apr 26.
A new metabolite, cyclic dipeptide, cis-(3S,8aS)-3-(3,4-dihydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, named JS-3 was isolated from Streptomyces sp. 8812 fermentation broth. Its chemical structure was established by means of spectroscopic analysis. A wide-range-screening study, which included inhibition assay of DD-carboxypeptidase/transpeptidase activity, determination of antibacterial, antifungal, and antiproliferative activities as well as free-radical scavenging was performed. To authors knowledge, this is the first isolation of such compound from natural sources and the first one from bacteria, Streptomyces.
一种新的代谢产物，环二肽，顺式-(3S,8aS)-3-(3,4-二羟基苄基)六氢吡咯并[1,2-a]吡嗪-1,4-二酮，命名为 JS-3，从链霉菌属 8812 发酵液中分离得到。其化学结构通过光谱分析确定。进行了广泛筛选研究，包括 DD-羧肽酶/转肽酶活性抑制测定、抗菌、抗真菌和抗增殖活性以及自由基清除活性测定。据作者所知，这是此类化合物首次从天然来源中分离得到，也是首次从细菌链霉菌属中分离得到。
