School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
J Mol Biol. 2018 Oct 12;430(20):3720-3734. doi: 10.1016/j.jmb.2018.04.012. Epub 2018 Apr 25.
Many living organisms make use of diverse amyloid proteins as functional building blocks to fulfill a variety of physiological applications. This fact, along with the intrinsic self-assembly and outstanding material properties of amyloids, has prompted a significant amount of research in the synthetic design of functional amyloids to form diverse nanoarchitectures, molecular materials, and hybrid or composite materials. In particular, a new research paradigm has recently been advanced that uses synthetic biology to harness functional amyloids with cells as living materials or functional devices. Here we outline important progress in the synthetic design of functional amyloids, in the context of both non-living and living systems. We propose several important tools and underline emerging techniques and principles that might be useful in advancing the future synthetic design of functional amyloids.
许多生物体利用多种淀粉样蛋白作为功能构建块来实现各种生理应用。这一事实，以及淀粉样蛋白的内在自组装和出色的材料特性，促使人们在合成设计功能性淀粉样蛋白以形成各种纳米结构、分子材料以及混合或复合材料方面进行了大量研究。特别是，最近提出了一个新的研究范例，即利用合成生物学将功能性淀粉样蛋白与细胞作为活体材料或功能器件结合起来。在这里，我们概述了在非生命和生命系统背景下功能性淀粉样蛋白的合成设计方面的重要进展。我们提出了几个重要的工具，并强调了一些新兴的技术和原则，这些可能有助于推进功能性淀粉样蛋白的未来合成设计。
