Finger Erik B, Bischof John C
Department of Surgery.
Departments of Mechanical and Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Curr Opin Organ Transplant. 2018 Jun;23(3):353-360. doi: 10.1097/MOT.0000000000000534.
The objective of this review is to describe the physical and biological barriers to organ cryopreservation, historic approaches for conventional cryopreservation and evolving techniques for ice-free cryopreservation by vitrification.
Vitrification is a process whereby a biologic substance is cooled to cryogenic temperatures without the destructive phase transition of liquid to solid ice. Recent advances in cryoprotective solutions, organ perfusion techniques and novel heating technologies have demonstrated the potential for vitrification and rewarming organs on a scale applicable for human transplantation.
Successful strategies for organ cryopreservation could enable organ banking, which would recast the entire process in which organs are recovered, allocated, stored and prepared for transplant.
本综述旨在描述器官冷冻保存的物理和生物屏障、传统冷冻保存的历史方法以及通过玻璃化实现无冰冷冻保存的不断发展的技术。
玻璃化是一种将生物物质冷却至低温而不发生从液体到固态冰的破坏性相变的过程。冷冻保护溶液、器官灌注技术和新型加热技术的最新进展已证明在适用于人类移植的规模上对器官进行玻璃化和复温的潜力。
成功的器官冷冻保存策略可实现器官库的建立，这将重塑器官回收、分配、储存和准备移植的整个过程。
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