Maimaiti Namaitijiang, Ahmed Zafar, Md Isa Zaleha, Ghazi Hasanain Faisal, Aljunid Syed
International Institute for Global Health, United Nations University, Kuala Lumpur, Malaysia; Department of Community Health, Faculty of Medicine, UKM.
International Institute for Global Health, United Nations University, Kuala Lumpur, Malaysia; International Centre for Case-Mix and Clinical Coding, UKM Medical Centre.
Value Health Reg Issues. 2013 Sep-Oct;2(2):259-263. doi: 10.1016/j.vhri.2013.07.003. Epub 2013 Sep 13.
To measure the clinical burden of invasive pneumococcal disease (IPD) in selected developing countries.
This is an extensive literature review of published articles on IPD in selected developing countries from East Asia, South Asia, Middle East, sub-Saharan Africa, and Latin America. We reviewed all the articles retrieved from the knowledge bases that were published between the years 2000 and 2010.
After applying the inclusion, exclusion, and quality criteria, the comprehensive review of the literature yielded 10 articles with data for pneumococcal meningitis, septicemia/bacteremia, and pneumonia. These selected articles were from 10 developing countries from five different regions. Out of the 10 selected articles, 8 have a detailed discussion on IPD, one of them has s detailed discussion on bacteremia and meningitis, and another one has discussed pneumococcal bacteremia. Out of these 10 articles, only 5 articles discussed the case-fatality ratio (CFR). In our article review, the incidence of IPD ranged from less than 5/100,000 to 416/100,000 population and the CFR ranged from 12.2% to 80% in the developing countries.
The review demonstrated that the clinical burden of IPD was high in the developing countries. The incidence of IPD and CFR varies from region to region and from country to country. The IPD burden was highest in sub-Saharan African countries followed by South Asian countries. The CFR was low in high-income countries than in low-income countries.
测量部分发展中国家侵袭性肺炎球菌病（IPD）的临床负担。
这是一项对已发表文章的广泛文献综述，这些文章来自东亚、南亚、中东、撒哈拉以南非洲和拉丁美洲的部分发展中国家，涉及IPD。我们回顾了从知识库中检索到的2000年至2010年间发表的所有文章。
在应用纳入、排除和质量标准后，对文献的全面综述产生了10篇有关肺炎球菌性脑膜炎、败血症/菌血症和肺炎数据的文章。这些选定的文章来自五个不同地区的10个发展中国家。在这10篇选定的文章中，8篇对IPD进行了详细讨论，其中1篇对菌血症和脑膜炎进行了详细讨论，另一篇讨论了肺炎球菌菌血症。在这10篇文章中，只有5篇讨论了病死率（CFR）。在我们的文章综述中，发展中国家IPD的发病率范围为每10万人中少于5例至416例，病死率范围为12.2%至80%。
该综述表明，IPD在发展中国家的临床负担很高。IPD的发病率和病死率因地区和国家而异。撒哈拉以南非洲国家的IPD负担最高，其次是南亚国家。高收入国家的病死率低于低收入国家。
