Amatayakul K, Petpoo W, Ratanawananukul N, Tanthayaphinant O, Tovanabutra S, Suriyanon V
Research Institute for Health Sciences, Chiang Mai University, Thailand.
Contraception. 1988 May;37(5):483-92. doi: 10.1016/0010-7824(88)90018-2.
Adrenal function and its reserve capacity were studied in eighteen healthy non-lactating women who received depot-medroxyprogesterone acetate (DMPA: 9 subjects) and norethisterone enanthate (NET-EN: 9 subjects) as long-acting injectable contraceptives. Methodological assessments included: (i) morning fasting concentration of serum cortisol; (ii) diurnal variation of adrenal corticol activity as evidenced by cortisol concentration in serum samples taken at 0700 and 1600 hours; (iii) urinary free cortisol excretion; and (iv) cortisol response to insulin-induced hypoglycaemia. None of these assessments was significantly altered by contraceptive administration. This finding indicates that the subject's ability to release cortisol in response to a stressful situation, as well as to normal day-to-day activity, was not impaired by these contraceptive steroids.
对18名健康非哺乳期女性的肾上腺功能及其储备能力进行了研究，这些女性接受了醋酸甲羟孕酮长效注射剂（DMPA：9名受试者）和庚酸炔诺酮（NET-EN：9名受试者）作为长效注射避孕药。方法学评估包括：（i）血清皮质醇的晨空腹浓度；（ii）肾上腺皮质醇活性的昼夜变化，通过0700和1600小时采集的血清样本中的皮质醇浓度来证明；（iii）尿游离皮质醇排泄；以及（iv）皮质醇对胰岛素诱导的低血糖的反应。这些评估均未因避孕药的使用而发生显著改变。这一发现表明，这些避孕类固醇并未损害受试者在应激情况下以及正常日常活动中释放皮质醇的能力。
