Crake T, Quyyumi A A, Rickards A F, Fox K M
National Hospital, London, UK.
Eur Heart J. 1988 Jan;9 Suppl A:101-3. doi: 10.1093/eurheartj/9.suppl_a.101.
The effects of isosorbide dinitrate on acute myocardial ischaemia were studied in 19 patients during coronary angioplasty. The duration of balloon inflation to the onset of ST segment depression was increased by the administration of intracoronary isosorbide dinitrate from (mean +/- SEM) 13 +/- 2 to 20 +/- 2 s (48%) (P less than 0.01) and the duration to 1 mm ST segment depression increased form 23 +/- 2 to 29 +/- 3 s (28%) (P less than 0.01). Systolic blood pressure fell from 118 +/- 3 to 111 +/- 4 mmHg but there was no change in intracoronary distal occlusion pressure. Thus during coronary occlusion isosorbide dinitrate prolongs the time to the onset of myocardial ischaemia.
在19例接受冠状动脉血管成形术的患者中研究了硝酸异山梨酯对急性心肌缺血的影响。冠状动脉内给予硝酸异山梨酯后，从球囊充气至ST段压低开始的时间从（均值±标准误）13±2秒增加到20±2秒（增加48%）（P<0.01），至ST段压低1毫米的时间从23±2秒增加到29±3秒（增加28%）（P<0.01）。收缩压从118±3毫米汞柱降至111±4毫米汞柱，但冠状动脉远端闭塞压无变化。因此，在冠状动脉闭塞期间，硝酸异山梨酯可延长心肌缺血开始的时间。
