Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Artillerigatan 6, 00250 Turku, Finland.
Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Artillerigatan 6, 00250 Turku, Finland; The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Stockholmsgatan 8, 00290 Helsinki, Finland.
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1668-1677. doi: 10.1016/j.bbamcr.2018.04.012. Epub 2018 Apr 26.
Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.
鞘磷脂的代谢产物以及钙离子流在几乎所有细胞类型的细胞信号转导中都起着重要作用。此外，鞘磷脂的代谢产物通常直接或间接地调节钙信号。这是脂质发挥其生理作用的一个有趣方面，因为钙可能是细胞中用途最广泛的信号分子之一，而钙信号的调节对细胞生理学有深远的影响。本文综述的目的是讨论鞘磷脂代谢产物，特别是鞘氨醇和鞘氨醇 1-磷酸（S1P）调节钙离子流的机制，以及这如何影响细胞功能。此外，还将讨论鞘脂触发钙流调节的病理方面。
