Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
Curr Opin Neurobiol. 2018 Dec;53:8-15. doi: 10.1016/j.conb.2018.03.011. Epub 2018 Apr 25.
The complexity and precision of cortical circuitries is achieved during development due to the exquisite diversity of synapse types that is generated in a highly regulated manner. Here, we review the recent increase in our understanding of how synapse type-specific molecules differentially regulate the development of excitatory and inhibitory synapses. Moreover, several synapse subtype-specific molecules have been shown to control the targeting, formation or maturation of particular subtypes of excitatory synapses. Because inhibitory neurons are extremely diverse, a similar molecular diversity is likely to underlie the development of different inhibitory synapses making it a promising topic for future investigation in the field of the synapse development.
皮质回路的复杂性和精确性是在发育过程中实现的，这是由于以高度调控的方式产生了精细多样的突触类型。在这里，我们回顾了最近对突触类型特异性分子如何差异调节兴奋性和抑制性突触发育的理解的增加。此外，已经显示几种突触亚型特异性分子控制特定类型的兴奋性突触的靶向、形成或成熟。由于抑制性神经元极其多样化，类似的分子多样性可能是不同抑制性突触发育的基础，这使其成为突触发育领域未来研究的一个有前途的课题。
