No Seung-Wook, Im Il-Kyu, Kim Du Hwan
Department of Rehabilitation Medicine, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, South Korea(∗).
Department of Rehabilitation Medicine, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, South Korea(†).
PM R. 2018 Dec;10(12):1426-1430. doi: 10.1016/j.pmrj.2018.04.007. Epub 2018 Apr 26.
Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by progressive muscular rigidity and spasms that affect axial and limb muscles. There have been a few reports that patients with SPS had evidences of polymyositis. There have been no clear explanations about the characteristics of polymyositis in SPS. We report the case of a 36-year-old woman with SPS in association with nonspecific focal myositis secondary to sustained muscle contraction. She presented with stiffness and pain in her extremities, and diazepam and baclofen were ineffective. With immunotherapy, her serum creatinine kinase levels reduced; however, her clinical symptoms progressively worsened. LEVEL OF EVIDENCE: V.
僵人综合征（SPS）是一种罕见的神经免疫性疾病，其特征为进行性肌肉僵硬和痉挛，累及躯干和四肢肌肉。已有少数报告称SPS患者有多发性肌炎的证据。关于SPS中多发性肌炎的特征尚无明确解释。我们报告一例36岁女性，患有SPS并伴有因持续肌肉收缩继发的非特异性局灶性肌炎。她表现为四肢僵硬和疼痛，地西泮和巴氯芬治疗无效。经免疫治疗后，她的血清肌酸激酶水平降低；然而，她的临床症状却逐渐恶化。证据级别：V级。
