Sun Xiaomin, Xiao Wenjuan, Li Zhongying, Zhou Sirui, Dong Mengyue, Huang Cong, Ma Yan, Gou Bo
Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Rehabilitation Center, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.
Front Physiol. 2022 Sep 28;13:1003572. doi: 10.3389/fphys.2022.1003572. eCollection 2022.
This study aimed to assess the effects of a 12-week vitamin D and endurance exercise intervention on bone health, body composition and physical performance among patients with type 2 diabetes. Totally, 61 patients were randomly assigned to vitamin D (VDG), exercise (EG), vitamin D and exercise intervention (VEG), and control (CG) groups. Bone health (bone mineral density, BMD; bone mineral content, BMC), body composition and physical performance were measured before and after the intervention. Dual energy X-ray absorptiometry was used to assess bone health and body composition. There were no additive effects of vitamin D beyond exercise were observed. Vitamin D supplementation had significant effects on maintaining bone health compared with their counterpart Total (BMC, EG + CG: 2,719.9 ± 70.0 vs. 2,670.1 ± 65.6; VDG + VEG: 2,610.9 ± 88.2 vs. 2,605.3 ± 84.8; trunk BMC, 870.2 ± 26.8 vs. 836.3 ± 23.7; 824.8 ± 29.5 vs. 822.1 ± 27.8; spine BMD, 1.15 ± 0.03 vs. 1.11 ± 0.02; 1.09 ± 0.03 vs. 1.09 ± 0.02) were observed. Exercise had a main effect on the reduction of total and trunk BF%. Patients in EG had a decreased BMC, while it was alleviated in VEG after intervention. Although no additive effect of vitamin D supplementation beyond exercise training, the supplementation had a potential effect on the prevention of bone loss induced by exercise only.
本研究旨在评估为期12周的维生素D与耐力运动干预对2型糖尿病患者骨骼健康、身体成分和身体机能的影响。总共61例患者被随机分为维生素D组（VDG）、运动组（EG）、维生素D与运动干预组（VEG）和对照组（CG）。在干预前后测量骨骼健康指标（骨密度，BMD；骨矿物质含量，BMC）、身体成分和身体机能。采用双能X线吸收法评估骨骼健康和身体成分。未观察到维生素D在运动之外的附加效应。与对照组相比，补充维生素D对维持骨骼健康有显著作用（总BMC，EG+CG组：2719.9±70.0 vs. 2670.1±65.6；VDG+VEG组：2610.9±88.2 vs. 2605.3±84.8；躯干BMC，870.2±26.8 vs. 836.3±23.7；824.8±29.5 vs. 822.1±27.8；脊柱BMD，1.15±0.03 vs. 1.11±0.02；1.09±0.03 vs. 1.09±0.02）。运动对降低总体和躯干体脂百分比有主要作用。EG组患者的BMC降低，而VEG组在干预后有所缓解。尽管补充维生素D在运动训练之外没有附加效应，但补充维生素D对预防仅由运动引起的骨质流失有潜在作用。
