对作为减肥药宣传的草药补充剂中的合成掺杂物进行主成分分析。
Principal component analysis of synthetic adulterants in herbal supplements advertised as weight loss drugs.
机构信息
Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
Forensic Toxicology Department, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
出版信息
Complement Ther Clin Pract. 2018 May;31:236-241. doi: 10.1016/j.ctcp.2018.03.007. Epub 2018 Mar 15.
OBJECTIVE
Obesity is one of the major problems in many countries. Herbal drugs are widely used to treat obesity. Unfortunately the majority of herbal weight loss drugs are adulterated with active pharmaceutical ingredients. The purpose of the present study was to analyse herbal weight loss drugs for the general search for pharmaceuticals.
METHODS
sixty one herbal weight loss drugs that were collected from herb shops and internet in Kermanshah, Iran were analysed qualitatively using gas chromatography/mass spectrometry.
RESULTS
Of the 61 weight loss products sampled, 72% were found to be adulterated with tramadol, caffeine, fluoxetine, rizatriptan, venlafaxine and methadone.
CONCLUSION
Herbal weight loss products were adulterated with controlled and legitimate drugs. Patients should be aware of the danger of using adulterated supplements.
目的
肥胖是许多国家的主要问题之一。草药被广泛用于治疗肥胖症。不幸的是，大多数草药减肥药都掺有活性药物成分。本研究的目的是分析减肥药中是否含有一般的药物。
方法
使用气相色谱/质谱法对从伊朗克尔曼沙阿的草药商店和互联网上收集的 61 种减肥药进行定性分析。
结果
在所采样的 61 种减肥药中，有 72%被发现掺有曲马多、咖啡因、氟西汀、利扎曲坦、文拉法辛和美沙酮。
结论
减肥药中掺有受管制和合法的药物。患者应意识到使用掺假补品的危险。
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