Ngo Ndjom Colette G, Gonzalez Xavier F, Jones Harlan P
Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Wort, TX, USA.
Department of Biomedical Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, USA.
Methods Mol Biol. 2018;1781:21-35. doi: 10.1007/978-1-4939-7828-1_2.
Multidiscipline-based research holds promise toward revealing complex mechanisms that determine health and disease. For decades, scientists have conducted studies defining the relationships between neuroendocrine and immune function culminating into the discipline of psychoneuroimmunology (PNI). In addition, the discipline of microbial endocrinology has similarly enhanced our understanding of disease processes. With an increase in genetic-based sequencing technologies, the convergence of neuroendocrine-immunological-microbial research is expected to significantly further such knowledge needed for medical discoveries. In this chapter, we provide a review of the current findings that support the conceptual framework linking microbiota, immunity, and neuroendocrine disciplines.
基于多学科的研究有望揭示决定健康和疾病的复杂机制。几十年来，科学家们开展了多项研究，以确定神经内分泌与免疫功能之间的关系，最终形成了心理神经免疫学（PNI）这一学科。此外，微生物内分泌学同样增进了我们对疾病过程的理解。随着基于基因的测序技术的发展，神经内分泌 - 免疫 - 微生物学研究的融合有望显著推动医学发现所需的此类知识的发展。在本章中，我们综述了当前支持将微生物群、免疫和神经内分泌学科联系起来的概念框架的研究结果。
