Vožeh F
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Physiol Res. 2018 May 4;67(2):165-173. doi: 10.33549/physiolres.933656. Epub 2018 Jan 5.
Immunity plays an important role in the reactivity of the organism and, in this context, is an essential factor in the pathogenesis of many diseases. Basically, there is no system or organ in the body, whose dysfunction is not related to immunity consequences. In addition, there are also multisystem diseases simultaneously involving multiple body systems. They are not always caused by weak immunity, but also often by modified immune reactions known as overshooting. The essence of all these diseases is a change in the reactivity of the organism where immunity plays an important role. The immunity as such is then part of the systems of neuroendocrine-immune regulation, which have common mediators and receptors. The establishment of psychoneuroimmunology, a relatively new discipline in neuroscience, contributed to a detailed understanding of these mechanisms between central and peripheral nervous system, the endocrine system and the immune system. This research enabled the uncovering of the nature of stress-diseases and impact of other regulatory disturbances on the function of various body organs and systems of the organism as a whole. The aim of this short review is to show complex interconnections of these relationships to better understand the human health and disease.
免疫在机体的反应性中起着重要作用，在这种情况下，它是许多疾病发病机制中的一个重要因素。基本上，身体内没有一个系统或器官，其功能障碍与免疫后果无关。此外，还有同时累及多个身体系统的多系统疾病。它们并不总是由免疫力低下引起的，也常常由被称为过度反应的免疫反应改变所致。所有这些疾病的本质都是机体反应性的改变，而免疫在其中起着重要作用。免疫本身就是神经内分泌 - 免疫调节系统的一部分，这些系统具有共同的介质和受体。心理神经免疫学这一神经科学中相对较新的学科的建立，有助于详细了解中枢和外周神经系统、内分泌系统和免疫系统之间的这些机制。这项研究揭示了应激性疾病的本质以及其他调节紊乱对整个机体各种身体器官和系统功能的影响。这篇简短综述的目的是展示这些关系的复杂相互联系，以便更好地理解人类健康与疾病。
