Beijing Key Laboratory of Emerging Organic Contaminants Control, State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510655, China.
J Hazard Mater. 2019 May 15;370:203-211. doi: 10.1016/j.jhazmat.2018.04.041. Epub 2018 Apr 22.
In present study, we investigated the enantioselective behaviors of the chiral antidepressant venlafaxine and its metabolite O-desmethylvenlafaxine in loach Misgurnus anguillicaudatus (M. anguillicaudatus), as well as effects of microplastic on toxicity, distribution and metabolism through a 40-day co-exposure. The contents of SOD and MDA in loach liver elevated when the loach was exposed to venlafaxine and O-desmethylvenlafaxine. Moreover, co-exposure with microplastic might lead to more adverse effect against loach. The distribution of venlafaxine and O-desmethylvenlafaxine were both detected in loach tissues and liver subcellular. The concentrations of venlafaxine and O-desmethylvenlafaxine were lower in water in microplastic-present treatment. Whilst, more contaminants were accumulated in liver through the "vehicle" (microplastic). Enantioselective behavior of venlafaxine and O-desmethylvenlafaxine occurred with R-enantiomers being preferentially degraded. With microplastic present, the bioaccumulation factor (BAF) of venlafaxine and O-desmethylvenlafaxine in loach tissue amplified more than 10 times. In liver subcellular structure, microplastic may help to transport more compounds into subtle areas and postpone the contaminants metabolism in organisms. The present study for the first time gained an insight into the potential ecological effects and environmental behaviors of combined pollutions of chiral pharmaceuticals and microplastic, which could supply important information for environment risk assessment of concurrent organic pollutants and microplastic.
在本研究中，我们研究了手性抗抑郁药文拉法辛及其代谢物 O-去甲文拉法辛在泥鳅（Misgurnus anguillicaudatus）中的对映体选择性行为，以及微塑料对毒性、分布和代谢的影响通过 40 天的共暴露。当泥鳅暴露于文拉法辛和 O-去甲文拉法辛时，其肝脏中的 SOD 和 MDA 含量增加。此外，与微塑料共暴露可能会对泥鳅造成更大的不利影响。文拉法辛和 O-去甲文拉法辛在泥鳅组织和肝亚细胞中的分布均被检测到。在存在微塑料的处理中，文拉法辛和 O-去甲文拉法辛在水中的浓度较低。然而，更多的污染物通过“载体”（微塑料）在肝脏中积累。文拉法辛和 O-去甲文拉法辛表现出对映体选择性行为，R-对映体优先降解。当存在微塑料时，文拉法辛和 O-去甲文拉法辛在泥鳅组织中的生物积累因子（BAF）增加了 10 多倍。在肝亚细胞结构中，微塑料可能有助于将更多的化合物运送到细微区域，并推迟污染物在生物体内的代谢。本研究首次深入了解了手性药物和微塑料联合污染的潜在生态效应和环境行为，为同时存在的有机污染物和微塑料的环境风险评估提供了重要信息。
