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抗凝药物的最新进展与市场分析

Recent progress and market analysis of anticoagulant drugs.

作者信息

Fan Ping, Gao Yangyang, Zheng Minglin, Xu Ting, Schoenhagen Paul, Jin Zhaohui

机构信息

Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.

Imaging Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

出版信息

J Thorac Dis. 2018 Mar;10(3):2011-2025. doi: 10.21037/jtd.2018.03.95.

DOI:10.21037/jtd.2018.03.95
PMID:29707358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5906253/
Abstract

This review describes epidemiology of thromboembolic disease in China and abroad, evaluates trends in the development of anticoagulant drugs, and analyzes the market situation based on large amounts of accumulated data. Specifically, we describe advances in clinical application of anticoagulants and analyze the most commonly used anticoagulants in the market systematically.

摘要

本综述描述了国内外血栓栓塞性疾病的流行病学，评估了抗凝药物的发展趋势，并基于大量积累的数据分析了市场情况。具体而言，我们描述了抗凝剂临床应用的进展，并系统分析了市场上最常用的抗凝剂。

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本文引用的文献

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Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.探索TGX-221相关的基于吡啶并[1,2-a]嘧啶酮的IA类PI 3-激酶抑制剂的亚型选择性：合成、生物学评价及分子模拟
Bioorg Med Chem. 2015 Jul 1;23(13):3796-808. doi: 10.1016/j.bmc.2015.03.073. Epub 2015 Apr 4.
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Antithrombotic drugs market.抗血栓药物市场。
Nat Rev Drug Discov. 2014 Aug;13(8):571-2. doi: 10.1038/nrd4365. Epub 2014 Jul 4.
3
Efficacy and safety of a routine early invasive strategy after fibrinolysis stratified by glycoprotein IIb/IIIa inhibitor use during percutaneous coronary intervention: a pre-specified subgroup analysis of the TRANSFER-AMI randomised controlled trial.溶栓后常规早期侵入策略的疗效和安全性：经皮冠状动脉介入治疗中使用糖蛋白 IIb/IIIa 抑制剂的分层：TRANSFER-AMI 随机对照试验的预先指定亚组分析。
Heart. 2014 Jun;100(11):873-80. doi: 10.1136/heartjnl-2013-305231. Epub 2014 Jan 21.
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Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.血管血栓素前列腺素受体激活对止血、血栓形成、氧化应激和炎症的影响。
J Thromb Haemost. 2014 Feb;12(2):126-37. doi: 10.1111/jth.12472.
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Cilostazol stroke prevention study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction.西洛他唑预防卒中研究：脑梗死二级预防的安慰剂对照双盲试验。
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Curr Med Res Opin. 2013 Oct;29(10):1253-61. doi: 10.1185/03007995.2013.818967. Epub 2013 Jul 18.
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2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.2012年美国心脏病学会基金会/美国心脏协会（ACCF/AHA）重点更新内容纳入ACCF/AHA 2007年不稳定型心绞痛/非ST段抬高型心肌梗死患者管理指南：美国心脏病学会基金会/美国心脏协会实践指南工作组报告
J Am Coll Cardiol. 2013 Jun 11;61(23):e179-347. doi: 10.1016/j.jacc.2013.01.014. Epub 2013 Apr 29.