Rodrigues Daniela A, Plácido Ana I, Tavares Ana Bárbara, Azevedo Daniela, Mateos-Campos Ramona, Figueiras Adolfo, Herdeiro Maria Teresa, Roque Fátima
Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda, Portugal.
Area of Preventive Medicine and Public Health, Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain.
Curr Ther Res Clin Exp. 2022 Jul 13;97:100681. doi: 10.1016/j.curtheres.2022.100681. eCollection 2022.
Portugal has among the highest rates of dependency among older adults in Europe. Older adults with aging-related comorbidities are prone to the use of potentially inappropriate medication (PIM).
The aim of this study was to analyze PIM prescriptions in older Portuguese adults, as well as the change rate of PIM prescriptions over time, and assess the geographical variability between the different regions of mainland Portugal.
Using a national database, PIM prescriptions were analyzed for older adults (aged 65 years and older) between 2019 and 2021 from 2 perspectives: PIM-defined daily dose (DDD) frequency (%) and DDD per 1000 inhabitants per day (DID).
Overall, mainland Portugal presented a PIM DDD frequency of 9.20%, which was relatively higher in Alentejo and Centro and lower in the North. Alprazolam, fluoxetine, and rivaroxaban were PIM with higher DDD frequency values. Over the years, the DID change rates for these three PIM were -3.80%, -14.86%, and +18.54%, respectively, depending on the geographic region. Alprazolam and fluoxetine were mostly prescribed to older women, whereas rivaroxaban was mostly prescribed to older men.
These results emphasize the need to implement initiatives and interventions to decrease PIM prescriptions in older adults.
葡萄牙是欧洲老年人依赖率最高的国家之一。患有与衰老相关合并症的老年人容易使用潜在不适当药物（PIM）。
本研究旨在分析葡萄牙老年成年人的PIM处方，以及PIM处方随时间的变化率，并评估葡萄牙大陆不同地区之间的地理差异。
利用国家数据库，从两个角度分析了2019年至2021年65岁及以上老年成年人的PIM处方：PIM限定日剂量（DDD）频率（%）和每1000居民每日DDD（DID）。
总体而言，葡萄牙大陆的PIM DDD频率为9.20%，在阿连特茹和中部地区相对较高，在北部地区较低。阿普唑仑、氟西汀和利伐沙班是DDD频率值较高的PIM。多年来，根据地理区域不同，这三种PIM的DID变化率分别为-3.80%、-14.86%和+18.54%。阿普唑仑和氟西汀大多开给老年女性，而利伐沙班大多开给老年男性。
这些结果强调需要采取举措和干预措施，以减少老年成年人的PIM处方。
