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雌激素对小鼠子宫中环磷酸腺苷反应元件结合蛋白张飞（CREBZF）表达的调控

Regulation of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) Expression by Estrogen in Mouse Uterus.

作者信息

Jang Hoon

机构信息

Dept. of Biomedical Science, College of Life Sciences, CHA University, Seongnam 13488, Korea.

出版信息

Dev Reprod. 2018 Mar;22(1):95-104. doi: 10.12717/DR.2018.22.1.095. Epub 2018 Mar 31.

DOI:10.12717/DR.2018.22.1.095
PMID:29707688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5915772/
Abstract

CREBZF (cAMP-response element binding protein zhangfei) is a member of ATF/CREB family, and which regulates various cellular functions by suppressing major factors with direct interaction. In this study, we have examined the expression of CREBZF on mouse endometrium during uterus estrous cycles and estrogen (E2) treatment. In uterus, mRNA expression was higher than other organs and mRNA and protein of CREBZF was increased in proestrus phase and decreased in estrus phase. The expression of CREBZF in 3-weeks old mouse uterus was reduced by E2 injection in endometrium. In addition, the expression of progesterone receptor, a marker of E2 in ovariectomized mice was found to be strongly expressed in stroma, while CREBZF was only expressed in epithelium. Also, we conformed that E2-suppressed CREBZF was restored by co-injection of ICI 182,780, an estrogen receptor antagonist. Overall, these results suggest that CREBZF is regulated by estrogen and involved in ER signaling pathway in mouse uterus.

摘要

CREBZF（cAMP反应元件结合蛋白张飞）是ATF/CREB家族的一员，它通过直接相互作用抑制主要因子来调节各种细胞功能。在本研究中，我们检测了小鼠子宫内膜在子宫发情周期和雌激素（E2）处理过程中CREBZF的表达。在子宫中，mRNA表达高于其他器官，CREBZF的mRNA和蛋白在动情前期增加，在发情期减少。3周龄小鼠子宫中CREBZF的表达在子宫内膜中通过注射E2而降低。此外，在去卵巢小鼠中，雌激素的标志物孕酮受体的表达在基质中强烈表达，而CREBZF仅在上皮中表达。而且，我们证实通过共同注射雌激素受体拮抗剂ICI 182,780可恢复E2抑制的CREBZF。总体而言，这些结果表明CREBZF受雌激素调节并参与小鼠子宫中的雌激素受体信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/7f9a41ce0a17/dr-22-1-95-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/f28cd44b1701/dr-22-1-95-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/e847bb6e266d/dr-22-1-95-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/b2777c9d16d2/dr-22-1-95-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/970077da13e5/dr-22-1-95-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/7f9a41ce0a17/dr-22-1-95-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/f28cd44b1701/dr-22-1-95-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/e847bb6e266d/dr-22-1-95-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/b2777c9d16d2/dr-22-1-95-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/970077da13e5/dr-22-1-95-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178d/5915772/7f9a41ce0a17/dr-22-1-95-g5.jpg

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PLoS One. 2016 Jun 15;11(6):e0157696. doi: 10.1371/journal.pone.0157696. eCollection 2016.
2
SMILE Is an Insulin-Inducible Transcriptional Corepressor of Hepatic Gluconeogenic Gene Programs.SMILE是肝脏糖异生基因程序的胰岛素诱导转录共抑制因子。
Diabetes. 2016 Jan;65(1):14-5. doi: 10.2337/dbi15-0022.
3
Int J Mol Sci. 2018 Nov 8;19(11):3517. doi: 10.3390/ijms19113517.
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Differentiation. 2016 Apr-Jun;91(4-5):42-9. doi: 10.1016/j.diff.2015.10.009. Epub 2015 Dec 2.
4
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5
Identification of egr1 direct target genes in the uterus by in silico analyses with expression profiles from mRNA microarray data.通过对mRNA微阵列数据的表达谱进行计算机分析来鉴定子宫中egr1的直接靶基因。
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