Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
Institute of Reproductive Genetics, Anhui Medical University, Hefei, Anhui, China (mainland).
Med Sci Monit. 2018 Apr 30;24:2668-2674. doi: 10.12659/MSM.907229.
BACKGROUND With the development of assisted reproductive technology, there is increasing evidence that frozen-thawed (FT) embryo transfer achieves a better outcome when compared with fresh embryo transfer in different types of infertile individuals. This aim of this study was to investigate the effect of FT embryo transfer for intracytoplasmic sperm injection (ICSI) on pregnancy outcome in assisted reproductive technology for male infertility. MATERIAL AND METHODS A total of 516 embryo transfer cycles (286 fresh embryo transfer cycles and 230 FT embryo transfer cycles) were studied, in which ICSI treatment was performed for the first time because of male infertility. The women in the study were normal or had Fallopian tube abnormalities. The clinical data and pregnancy outcomes of these two study groups were compared. RESULTS The implantation rate, pregnancy rate, and multiple birth rate of the FT embryo transfer group were similar when compared with the fresh embryo transfer group. The live birth rate of the FT embryo transfer group was significantly greater when compared with the fresh embryo transfer group (P<0.05). The rate of miscarriage of the FT embryo transfer group was 6.52%, which was significantly less than that of the fresh embryo transfer group (14.01%) (P<0.05). The gestational age and neonatal birth weight were not significantly different between the two groups (P>0.05). CONCLUSIONS FT embryo transfer was an effective and safe treatment for patients undergoing ICSI, which improved the live birth rate and reduced the rate of miscarriage.
随着辅助生殖技术的发展，越来越多的证据表明，与新鲜胚胎移植相比，冷冻-解冻（FT）胚胎移植在不同类型的不孕个体中能获得更好的结局。本研究旨在探讨对于因男性不育而首次进行胞浆内单精子注射（ICSI）的患者，FT 胚胎移植对辅助生殖技术中男性不育妊娠结局的影响。
共研究了 516 个胚胎移植周期（286 个新鲜胚胎移植周期和 230 个 FT 胚胎移植周期），这些患者因男性不育首次接受 ICSI 治疗。研究中的女性正常或有输卵管异常。比较了这两组患者的临床资料和妊娠结局。
FT 胚胎移植组的着床率、妊娠率和多胎率与新鲜胚胎移植组相似。FT 胚胎移植组的活产率明显高于新鲜胚胎移植组（P<0.05）。FT 胚胎移植组的流产率为 6.52%，明显低于新鲜胚胎移植组（14.01%）（P<0.05）。两组的胎龄和新生儿出生体重无显著差异（P>0.05）。
FT 胚胎移植是 ICSI 患者的一种有效且安全的治疗方法，可提高活产率，降低流产率。
