Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.
Curr Opin Ophthalmol. 2018 Jul;29(4):365-372. doi: 10.1097/ICU.0000000000000485.
Adenoviral keratitis is a common and bothersome ocular infection that produces a lot of burden on healthcare systems and patients. The goal of this article is to provide a review of the topic, with an emphasis on current attempts at advancing strategies in diagnosis and management.
Sixty-eight articles and one textbook published on adenoviral keratitis were reviewed. The findings on the epidemiology, pathophysiology, clinical features, diagnosis, and management were summarized. Any contradicting opinions for which the literature was unclear were either omitted or recorded as lacking strong evidence.
Although significant effort has been made to develop new methods for diagnosis and management, adenoviral keratitis is predominantly diagnosed clinically with prevention being the mainstay of management. The use of newer DNA analysis techniques and topical anti-inflammatory agents for treatment of corneal infiltrates show promising results, but a better understanding of the pathogenesis and clinical features can lead to more targeted methods of diagnosis and therapy.
腺病毒角膜炎是一种常见且令人困扰的眼部感染，给医疗系统和患者带来了很大负担。本文的目的是对该主题进行综述，重点介绍当前在诊断和治疗策略方面的进展。
回顾了 68 篇关于腺病毒角膜炎的文章和 1 本教科书。总结了流行病学、发病机制、临床特征、诊断和治疗方面的发现。对于文献不清楚的任何相互矛盾的观点，要么被省略，要么被记录为缺乏强有力的证据。
尽管在开发新的诊断和治疗方法方面做了大量工作，但腺病毒角膜炎主要通过临床诊断，预防是治疗的主要手段。使用新的 DNA 分析技术和局部抗炎药物治疗角膜浸润显示出有希望的结果，但对发病机制和临床特征的更好理解可以导致更有针对性的诊断和治疗方法。
