Hu Shou-Long, Tang Li-Ying, Fang Jian-Wen, Su Ting, Ge Qian-Min, Lin Qi, Li Biao, Shi Wen-Qing, Li Qiu-Yu, Liang Rong-Bin, Shao Yi
National Center for Children's Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, People's Republic of China.
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Jun 23;16:1571-1581. doi: 10.2147/NDT.S238463. eCollection 2020.
To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging.
A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample -test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients.
The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions.
CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.
使用静息态功能磁共振成像研究角膜溃疡（CU）患者与健康对照者（HCs）之间初级视觉皮层功能连接（FC）的差异。
总共30例CU患者和30例HCs在性别、年龄和教育程度方面进行了密切匹配。采用双样本t检验、受试者工作特征曲线和Pearson相关系数分析来确定两组之间FC的差异、CU患者和HCs的平均FC值，以及患者不同脑区FC信号值与临床表现之间的相关性。
与HC组相比，CU组在左右额中回的FC显著升高，与右侧楔叶的FC降低。此外，CU组右侧扣带回和左侧额上回的FC也增加。受试者工作特征曲线显示这些脑区具有较高的诊断价值。
CU涉及不同脑区初级视觉皮层的异常FC，包括视觉相关和认知相关区域。这一发现可能揭示了CU患者视觉功能受损的潜在神经机制。
