患有乳腺大囊性病的女性体内δ5和δ4甾体激素的血浆及囊液水平

Plasma and cyst fluid levels of delta 5 and delta 4 steroid hormones in women with gross cystic breast disease.

作者信息

Inaudi P, Bernabei A, Gioffré W, Franchi F, Mazzullo G, De Leo V, D'Antona N

机构信息

Department of Obstetrics and Gynaecology, University of Siena, Italy.

出版信息

Clin Endocrinol (Oxf). 1987 Dec;27(6):643-8. doi: 10.1111/j.1365-2265.1987.tb02946.x.

DOI:10.1111/j.1365-2265.1987.tb02946.x

PMID:2970900

Abstract

delta 5 and delta 4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean +/- SEM) of DHA (11.2 +/- 2.4 ng/ml), DHAS (1.45 +/- 0.6 micrograms/ml) and cortisol 277 +/- 15.7 ng/ml) was found; in follicular phase the mean levels were 4.09 +/- 0.47 ng/ml for DHA, 0.65 +/- 0.08 microgram/ml for DHAS and 190 +/- 46.3 micrograms/ml for cortisol. The DHA/DHAS and cortisol/androstenedione ratios were significantly higher in the plasma and lower in the cyst fluid of GCBD patients, than in the plasma of controls; the androstenedione/DHA ratio was higher in the cyst fluid than in the plasma of controls. The hormonal situation of the GCBD patients thus differed from that of the controls both in the plasma and cyst fluid, particularly as regards the delta 5 steroids.

摘要

对患有乳腺大囊性病（GCBD）的女性的血浆和囊肿液中的δ5和δ4类固醇水平进行了研究。在黄体期，发现血浆中DHA（11.2±2.4 ng/ml）、脱氢表雄酮硫酸盐（DHAS，1.45±0.6μg/ml）和皮质醇（277±15.7 ng/ml）水平显著升高；在卵泡期，DHA的平均水平为4.09±0.47 ng/ml，DHAS为0.65±0.08μg/ml，皮质醇为190±46.3μg/ml。与对照组血浆相比，GCBD患者血浆中的DHA/DHAS和皮质醇/雄烯二酮比值显著更高，而囊肿液中的这些比值则更低；囊肿液中的雄烯二酮/DHA比值高于对照组血浆中的该比值。因此，GCBD患者在血浆和囊肿液中的激素状况与对照组不同，尤其是在δ5类固醇方面。