Secreto G, Recchione C, Ballerini P, Callegari L, Cavalleri A, Attili A, Fariselli G, Moglia D, Del Prato I
Division of Experimental Oncology C, National Cancer Institute, Milan, Italy.
Eur J Cancer. 1991;27(1):44-7. doi: 10.1016/0277-5379(91)90058-l.
80 breast cyst fluids (BCF) from 57 patients were divided by K+/Na+ ratio: 56 with ratio over 1 (type I) and 24 with ratio less than 1 (type II). Significantly higher amounts of testosterone, dihydrotestosterone and dehydroepiandrosterone sulphate (DHAS) were found in type I than in type II cysts. A positive relation was found between testosterone and dihydrotestosterone in both types. DHAS was significantly correlated with testosterone and dihydrotestosterone in type I casts only. In 52 patients, blood was sampled after cyst evacuation. Testosterone was significantly higher in blood than in BCF while dihydrotestosterone and androstenedione were significantly higher in BCF. No relation was observed between circulating levels of androgens and their intracystic concentrations. Women bearing type I cysts may be at increased risk of developing cancer. These findings support the hypothesis that androgens play a role in the hormonal aetiology of breast cancer.
来自57名患者的80份乳腺囊肿液（BCF）按钾离子/钠离子比值进行划分：56份比值大于1（I型），24份比值小于1（II型）。I型囊肿中发现的睾酮、双氢睾酮和硫酸脱氢表雄酮（DHAS）含量显著高于II型囊肿。两种类型中睾酮和双氢睾酮之间均发现呈正相关。仅在I型囊肿中，DHAS与睾酮和双氢睾酮显著相关。52例患者在囊肿排空后采集血液样本。血液中的睾酮显著高于BCF，而双氢睾酮和雄烯二酮在BCF中显著更高。未观察到雄激素的循环水平与其囊内浓度之间存在关联。患有I型囊肿的女性患癌风险可能增加。这些发现支持了雄激素在乳腺癌激素病因学中起作用这一假说。
