The University of Sydney, Faculty of Health Sciences & Charles Perkins Centre, Sydney, Australia.
The University of Sydney, National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, Australia.
Vaccine. 2018 May 31;36(23):3254-3259. doi: 10.1016/j.vaccine.2018.04.069. Epub 2018 Apr 27.
With increased school-based vaccinations for improved coverage rates and practicality, the World Health Organization (WHO) recently endorsed research to identify possible interventions to reduce vaccine-related pain in mass clinical and school-based settings. In particular, the lack of research in adolescents indicate a particular need in this population. Acute exercise has analgesic effects and has been used as a behavioural adjuvant to vaccination. Here, we examine the effect of exercise on vaccine-related pain, anxiety and fear in adolescents, during a school-based program for HPV vaccinations.
116 students (Female: 61, Male: 55) aged 11-13 years were randomly allocated to either an Exercise (n = 60) or Control (n = 56) group. All participants completed demographic and Trait-anxiety questionnaires prior to receiving the vaccine according to usual care. The Exercise group also performed upper body exercise for 15 min prior to receiving the vaccine. Immediately after the vaccine administration, all participants reported on pain, anxiety and fear at the time of receiving the vaccine.
Female adolescents in the Exercise group reported significantly less pain (3.64; 95% CI, 2.98-4.30) than Controls (4.58; 95% CI, 3.96-5.19; p = 0.04). Further, females reported greater pain and anxiety than males in the Control group but not the Exercise group.
This study supports the use of exercise prior to vaccine administration, especially in female adolescents who are particularly vulnerable to negative experiences during vaccination procedures. Furthermore, the ease of application, as well as the benefit of exercise, provides support for the use of simple exercise prior to vaccination in mass vaccination settings. Clinical trial registry: ANZCTR, ACTRN12614001185651.
随着学校疫苗接种率的提高和实用性的提高，世界卫生组织（WHO）最近支持了一项研究，旨在确定可能的干预措施，以减少大规模临床和学校环境中与疫苗相关的疼痛。特别是，青少年缺乏研究表明该人群有特别的需求。急性运动具有镇痛作用，并已被用作疫苗接种的行为佐剂。在这里，我们研究了运动对青少年在学校 HPV 疫苗接种计划中与疫苗相关的疼痛、焦虑和恐惧的影响。
116 名年龄在 11-13 岁的学生（女性：61 名，男性：55 名）被随机分配到运动（n=60）或对照组（n=56）。所有参与者在按常规护理接种疫苗前完成人口统计学和特质焦虑问卷。运动组还在接种疫苗前进行了 15 分钟的上半身运动。接种疫苗后立即，所有参与者报告了接种疫苗时的疼痛、焦虑和恐惧。
运动组的女性青少年报告的疼痛明显少于对照组（3.64；95%置信区间，2.98-4.30）（4.58；95%置信区间，3.96-5.19；p=0.04）。此外，在对照组中，女性报告的疼痛和焦虑比男性大，但在运动组中并非如此。
这项研究支持在接种疫苗前进行运动，特别是对在接种疫苗过程中特别容易产生负面体验的女性青少年。此外，运动的简便性以及运动的益处为在大规模疫苗接种环境中在接种疫苗前使用简单运动提供了支持。临床试验注册号：ANZCTR，ACTRN12614001185651。
