Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Department of Electronics Engineering, Konkuk University, Seoul, Republic of Korea.
J Neurosci Methods. 2018 Jul 1;304:118-125. doi: 10.1016/j.jneumeth.2018.04.014. Epub 2018 Apr 27.
Neural responses to electrical stimulation provide valuable information to probe and study the network function. Especially, recording neural responses from the stimulated site provides improved neural interfacing method. However, it is difficult to measure short-delayed responses at the stimulated electrode due to the saturation of the amplifier after stimulation which is called "stimulus artifact". Despite the advances in handling stimulation artifacts, it is still very challenging to deal with the artifacts if one tries to stimulate and record from the same electrode.
In this paper, we developed a system consisting of 24 bit ADC and low gain DC-amplifier which allows us to record the entire responses including saturation-free stimulus artifact and neural responses with excellent resolution.
Our approach showed saturation-free recording after stimulation, which makes it possible to recover neural spike as early as in 2 ms at the stimulating electrode with digital elimination methods.
With our system we could record neural signals after stimulation that was difficult with high gain and high pass filtered recording system due to amplifier saturation.
Our new system can enhance interface performance with its higher robustness and with simple system configuration.
电刺激的神经反应提供了有价值的信息，可用于探测和研究网络功能。特别是，从刺激部位记录神经反应提供了改进的神经接口方法。然而，由于刺激后放大器饱和，即所谓的“刺激伪影”，很难测量刺激电极处的短延迟响应。尽管在处理刺激伪影方面取得了进展，但如果试图从同一电极进行刺激和记录，仍然非常具有挑战性。
在本文中，我们开发了一个由 24 位 ADC 和低增益直流放大器组成的系统，该系统允许我们记录包括无饱和刺激伪影和具有出色分辨率的神经反应在内的整个响应。
我们的方法在刺激后显示出无饱和记录，这使得通过数字消除方法在刺激电极处尽早恢复神经尖峰成为可能，最早可达 2ms。
使用我们的系统，我们可以记录刺激后的神经信号，而使用高增益和高通滤波记录系统由于放大器饱和而难以实现。
我们的新系统可以通过更高的鲁棒性和简单的系统配置来提高接口性能。
