Merritt C M, Board P G
John Curtin School of Medical Research, Australian National University, Canberra A.C.T.
Gene. 1988 Jun 15;66(1):97-106. doi: 10.1016/0378-1119(88)90228-4.
Human alpha 1-acid glycoprotein (AGP), also known as orosomucoid, is a major acute-phase plasma protein. The amino acid sequence of AGP, which was determined by sequencing from protein isolated from pooled plasma, contained amino acid substitutions in 21 different positions. Genomic and cDNA clones which correspond to one of the possible amino acid sequences have been previously reported. In this paper we present the complete nucleotide sequence of a second gene, AGP2 which is located approx. 3.3 kb downstream from AGP1. The derived amino acid sequence of AGP2 contains 19 of the possible alternative amino acid substitutions as well as two additional differences. It is clear from the results presented here that the AGP in human plasma is the product of two separate gene loci.
人α1-酸性糖蛋白（AGP），也称为orosomucoid，是一种主要的急性期血浆蛋白。通过对从混合血浆中分离出的蛋白质进行测序确定的AGP氨基酸序列，在21个不同位置含有氨基酸替代。先前已经报道了与其中一种可能的氨基酸序列相对应的基因组和cDNA克隆。在本文中，我们展示了第二个基因AGP2的完整核苷酸序列，它位于AGP1下游约3.3 kb处。AGP2推导的氨基酸序列包含19种可能的替代氨基酸替代以及另外两个差异。从这里给出的结果可以清楚地看出，人血浆中的AGP是两个独立基因座的产物。
