大鼠α1-酸性糖蛋白基因的结构
Structure of the rat alpha 1-acid glycoprotein gene.
作者信息
Liao Y C, Taylor J M, Vannice J L, Clawson G A, Smuckler E A
出版信息
Mol Cell Biol. 1985 Dec;5(12):3634-9. doi: 10.1128/mcb.5.12.3634-3639.1985.
Abstract
The complete nucleotide sequence of the rat alpha 1-acid glycoprotein gene has been determined from an isolated lambda recombinant bacteriophage. Southern blot analysis and DNA sequencing indicate that there is only one gene per genome; it contains six exons and is located within a 3,200-base-pair fragment starting from a TATA box and extending to the polyadenylation signal AATAAA. Transcription starts 37 base pairs upstream from the beginning of the translation codon ATG. The TATA box (TATAAA) lies 26 base pairs upstream from this site. The gene contains several potential glucocorticoid receptor-binding sites, both inside and outside the structural gene.
摘要
大鼠α1-酸性糖蛋白基因的完整核苷酸序列已从分离出的λ重组噬菌体中测定。Southern印迹分析和DNA测序表明，每个基因组仅有一个基因；它包含六个外显子，位于一个3200碱基对的片段内，起始于TATA盒，延伸至聚腺苷酸化信号AATAAA。转录起始于翻译密码子ATG起始位点上游37个碱基对处。TATA盒（TATAAA）位于该位点上游26个碱基对处。该基因在结构基因内外均含有几个潜在的糖皮质激素受体结合位点。
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