Collman James P, Fu Lei, Herrmann Paul C, Wang Zhong, Rapta Miroslav, Bröring Martin, Schwenninger Reinhold, Boitrel Bernard
Department of Chemistry, Stanford University, Stanford, CA 94305-5080 (USA), Fax: (+1) 650-725-0259.
Angew Chem Int Ed Engl. 1998 Dec 31;37(24):3397-3400. doi: 10.1002/(SICI)1521-3773(19981231)37:24<3397::AID-ANIE3397>3.0.CO;2-N.
The environment of the Cu ion in the distal ligand group decides the fate of the reduction of O by the two analogues 1 and 2 of the heme a Cu center in cytochrome c oxidase. The fourfold coordination by N in 1 favors the Cu oxidation state and leads to a 4 e -4 H reduction and the formation of H O under physiological conditions, while with 2 a 2 e -2 H reduction occurs to form the cytotoxic H O .
细胞色素c氧化酶中血红素a铜中心的两种类似物1和2的远端配体基团中铜离子的环境决定了氧还原的结果。1中氮的四重配位有利于铜的氧化态，并导致在生理条件下进行4e-4H还原并形成H₂O，而对于2则发生2e-2H还原以形成具有细胞毒性的H₂O₂。
