Josephson Lee, Perez J Manuel, Weissleder Ralph
Harvard Medical School MGH Center For Molecular Imaging Research Building 149, 13th Street, Boston, MA 02129 (USA) Fax: (+1) 617-727-5799.
Angew Chem Int Ed Engl. 2001 Sep 3;40(17):3204-3206. doi: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H.
Superparamagnetic nanoparticles conjugated to oligonucleotides exert sensitive and reversible effects on the spin-spin relaxation rates of adjacent water protons when the conjugates hybridize to target oligonucleotides (see temperature cycle in the picture). The fluid-phase magnetic sensors provide the basis for detecting specific nucleic acid sequences in turbid media and potentially in tissues in vivo.
与寡核苷酸结合的超顺磁性纳米颗粒在与靶寡核苷酸杂交时，会对相邻水质子的自旋-自旋弛豫速率产生灵敏且可逆的影响（见图中的温度循环）。液相磁传感器为在浑浊介质中以及潜在地在体内组织中检测特定核酸序列提供了基础。
Zotero 插件