基于磁弛豫开关分析的纳米传感器的最新进展

Recent Advances on Magnetic Relaxation Switching Assay-Based Nanosensors.

作者信息

Zhang Yang, Yang Hong, Zhou Zhiguo, Huang Kai, Yang Shiping, Han Gang

机构信息

The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.

出版信息

Bioconjug Chem. 2017 Apr 19;28(4):869-879. doi: 10.1021/acs.bioconjchem.7b00059. Epub 2017 Feb 28.

DOI:10.1021/acs.bioconjchem.7b00059

PMID:28205434

Abstract

Magnetic relaxation switching assay (MRSw)-based nanosensors respond to the changes of transverse relaxation time (T) of water molecules resulted from the analyte-induced aggregation and disaggregation of magnetic nanoparticles (MNPs). This strategy has been widely applied to the detections of various substrates from heavy metal ions to organic pollutants, proteins, nucleic acids, bacteria and viruses, and specific cells. Compared with other nanosensors, MRSw-based nanosensors not only are free from the background interferences, signal bleaching, and quenching but also overcome light scattering from samples without pretreatments. Therefore, MRSw-based nanosensors have been developed as real-time and on-site detection platforms for environmental protection, food safety, and risk assessment. This review summarizes the latest developments of the principles, the applicable magnetic nanoparticles, and the exploited environmental and biological applications of MRSw-based nanosensors.

摘要

基于磁弛豫开关分析（MRSw）的纳米传感器可响应由分析物诱导的磁性纳米颗粒（MNP）聚集和解聚导致的水分子横向弛豫时间（T2）变化。该策略已广泛应用于从重金属离子到有机污染物、蛋白质、核酸、细菌和病毒以及特定细胞等各种底物的检测。与其他纳米传感器相比，基于MRSw的纳米传感器不仅不受背景干扰、信号漂白和猝灭的影响，而且无需预处理即可克服样品的光散射。因此，基于MRSw的纳米传感器已被开发为用于环境保护、食品安全和风险评估的实时现场检测平台。本文综述了基于MRSw的纳米传感器在原理、适用的磁性纳米颗粒以及已开发的环境和生物应用方面的最新进展。