Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine, Washington, D.C. 20037.
Cold Spring Harb Perspect Med. 2019 May 1;9(5):a031740. doi: 10.1101/cshperspect.a031740.
Disease outbreaks resembling hepatitis A have been known since antiquity. However, it was not until World War II when two forms of viral hepatitis were clearly differentiated. After the discovery of Australia antigen and its association with hepatitis B, similar methodologies were used to find the hepatitis A virus. The virus was ultimately identified when investigators changed the focus of their search from serum to feces and applied appropriate technology.
类似于甲型肝炎的疾病暴发自古就有记载。然而,直到第二次世界大战,两种形式的病毒性肝炎才被明确区分开来。在发现澳大利亚抗原及其与乙型肝炎的关联后,类似的方法被用于寻找甲型肝炎病毒。当研究人员将搜索重点从血清转移到粪便并应用适当的技术时,最终确定了该病毒。