Nikpayam Omid, Rouhani Mohammad Hossein, Pourmasoumi Makan, Roshanravan Neda, Ghaedi Ehsan, Mohammadi Hamed
Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Clin Nutr Res. 2018 Apr;7(2):117-125. doi: 10.7762/cnr.2018.7.2.117. Epub 2018 Apr 16.
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-analysis was to clarify the effect of Pycnogenol supplementation on C-reactive protein (CRP) concentration. To identify eligible studies in order to find clinical trials which examined the effect of Pycnogenol supplementation on the level of CRP in adult participants, PubMed, Scopus, and Google Scholar were systematically searched until December 2017. Mean of CRP was collected to estimate the effect size of the supplementation. Potential sources of heterogeneity were explored by subgroup analysis. Five trials including 324 participants were included in this meta-analysis. Pooled effect size showed significant effect of Pycnogenol supplementation on CRP (-1.22 mg/dL, 95% confidence interval, -2.43, -0.003; I = 99%, p < 0.001). When the meta-analysis was subgrouped by dose of Pycnogenol, heterogeneity was attenuated in > 150 mg/d category (I = 0.0%, p = 0.42). There was significant difference between-subgroup heterogeneity (p < 0.001). Furthermore, no evidence of publication bias for CRP (p = 0.27, Begg's test and p = 0.62, Egger's test) was seen. Present systematic review and meta-analysis suggested Pycnogenol consumption can decrease the level of CRP and have anti-inflammatory effect. So, Pycnogenol as an anti-inflammatory agent might be a priority in interventions. Further studies with large-scale and better design are needed to confirm this result.
碧萝芷是一种从法国滨海松树树皮中提取的标准化提取物。本系统评价和荟萃分析的目的是阐明补充碧萝芷对C反应蛋白（CRP）浓度的影响。为了找出符合条件的研究，以便找到检验补充碧萝芷对成年参与者CRP水平影响的临床试验，我们系统检索了PubMed、Scopus和谷歌学术，直至2017年12月。收集CRP均值以估计补充剂的效应大小。通过亚组分析探索潜在的异质性来源。本荟萃分析纳入了5项试验，共324名参与者。合并效应大小显示补充碧萝芷对CRP有显著影响（-1.22mg/dL，95%置信区间，-2.43，-0.003；I² = 99%，p < 0.001）。当按碧萝芷剂量对荟萃分析进行亚组划分时，在>150mg/d组中异质性减弱（I² = 0.0%，p = 0.42）。亚组间异质性存在显著差异（p < 0.001）。此外，未发现CRP存在发表偏倚的证据（Begg检验p = 0.27，Egger检验p = 0.62）。目前的系统评价和荟萃分析表明，食用碧萝芷可降低CRP水平并具有抗炎作用。因此，碧萝芷作为一种抗炎剂可能是干预措施中的优先选择。需要进一步开展大规模、设计更好的研究来证实这一结果。
