Halal Research Center of IRI, FDA, Tehran, Iran.
Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Phytother Res. 2019 Feb;33(2):276-287. doi: 10.1002/ptr.6234. Epub 2018 Nov 19.
The effects of pycnogenol on plasma lipids are controversial. A systematic review and meta-analysis of clinical trials were conducted to obtain a conclusive result in humans. PubMed, Scopus, and Google Scholar were systematically searched until March 2018, to explore the clinical trials that examined the effect of pycnogenol supplementation on lipid parameters among adult human. Methodological quality of the eligible studies was evaluated using the Cochrane Collaboration's tool. To estimate the effect size, changes in blood lipids were implemented. Results were pooled using a random effects model. Potential sources of heterogeneity were explored by subgroup analysis. A systematic review and meta-analysis of 14 clinical trials with 1,065 participants suggested a significant increase in plasma concentration of high density lipoprotein cholesterol (HDL-C; 3.27 mg/dL; 95% CI [0.19, 6.36]; p = 0.038). In contrast, plasma levels of total cholesterol (TC; -4.45 mg/dL, 95% CI [-11.24, 2.34]; p = 0.199), triacylglycerol (TAG; -3.64 mg/dL; 95% CI [-17.89, 10.61]; p = 0.616), and low density lipoprotein cholesterol (LDL-C; -3.61 mg/dl; 95% CI [-8.76, 1.55]; p = 0.171) were not altered. Adjustment for confounding variables was poor in included studies. Also, these studies did not assess dietary lipid intake. The results indicate that pycnogenol supplementation improves levels of HDL-C; however, the changes in TC, TAG, and LDL-C were not clinically relevant. Since there are few phytochemicals that have a significant increasing effect on HDL-C levels, pycnogenol may have important role in prevention of cardiovascular diseases.
碧萝芷对血浆脂质的影响存在争议。我们进行了系统评价和荟萃分析，以在人类中获得确凿的结果。系统地检索了 PubMed、Scopus 和 Google Scholar，直到 2018 年 3 月，以探讨检查成人补充碧萝芷对血脂参数影响的临床试验。使用 Cochrane 协作组的工具评估合格研究的方法学质量。为了估计效应大小，实施了血液脂质的变化。使用随机效应模型汇总结果。通过亚组分析探索潜在的异质性来源。对 14 项临床试验（1065 名参与者）的系统评价和荟萃分析表明，高密度脂蛋白胆固醇（HDL-C）的血浆浓度显着升高（3.27mg/dL；95%置信区间[0.19, 6.36]；p=0.038）。相比之下，血浆总胆固醇（TC）水平（-4.45mg/dL，95%置信区间[-11.24, 2.34]；p=0.199），三酰基甘油（TAG）（-3.64mg/dL；95%置信区间[-17.89, 10.61]；p=0.616）和低密度脂蛋白胆固醇（LDL-C）（-3.61mg/dl；95%置信区间[-8.76, 1.55]；p=0.171）没有改变。纳入研究对混杂变量的调整较差。此外，这些研究没有评估饮食脂质摄入。结果表明，碧萝芷补充剂可改善 HDL-C 水平；然而，TC、TAG 和 LDL-C 的变化在临床上并不相关。由于很少有植物化学物质对 HDL-C 水平有显着的升高作用，因此碧萝芷在预防心血管疾病方面可能具有重要作用。
