Machin D, Farley T M, Busca B, Campbell M J, d'Arcangues C
Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Geneva, Switzerland.
Contraception. 1988 Aug;38(2):165-79. doi: 10.1016/0010-7824(88)90037-6.
In clinical trials comparing alternative contraceptive methods, women often discontinue for disturbances in menstrual bleeding patterns. Vaginal bleeding diaries have been used to monitor these patterns, and this paper suggests two new methods of analysis of these data. One analysis measures trends over time in the occurrence of specific patterns and, a second analysis, the relation between a woman's current experience and the probability of continuing method use. Contrasts between these approaches and the reference period method of analysis are made. A randomised clinical trial of the relative efficacy of 100 and 150 mg doses of depot-medroxyprogesterone acetate (DMPA) is used for illustration.
在比较不同避孕方法的临床试验中，女性常因月经出血模式紊乱而停药。阴道出血日记已被用于监测这些模式，本文提出了两种分析这些数据的新方法。一种分析方法测量特定模式出现的时间趋势，另一种分析方法则测量女性当前的使用体验与继续使用该方法的概率之间的关系。文中还对这些方法与参考期分析法进行了对比。以一项关于100毫克和150毫克剂量醋酸甲羟孕酮长效避孕针（DMPA）相对疗效的随机临床试验为例进行说明。
