Tungsukruthai Sucharat, Petpiroon Nalinrat, Chanvorachote Pithi
Interdisciplinary Program of Pharmacology Graduate School, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Anticancer Res. 2018 May;38(5):2607-2618. doi: 10.21873/anticanres.12502.
Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. Metastatic breast cancer cells acquire their aggressive features through several mechanisms, including augmentation of survival, proliferation, tumorigenicity, and motility-related cellular pathways. Clearly, natural product-derived compounds have since long been recognized as an important source for anticancer drugs, several of which have been shown to have promising anti-metastasis activities by suppressing key molecular features supporting such cell aggressiveness. This review provides the essential details of breast cancer, the molecular-based insights into metastasis, as well as the effects and mechanisms of potential compounds for breast cancer therapeutic approaches. As the abilities of cancer cells to invade and metastasize are addressed as the hallmarks of cancer, compounds possessing anti-metastatic effects, together with their defined molecular drug action could benefit the development of new drugs as well as treatment strategies.
在全球范围内，乳腺癌是癌症相关死亡的主要原因之一，也是女性中最常见的癌症。癌症分子知识的发展已经超越了癌症生物学的新概念，并揭示了抗癌药物开发和治疗策略的主要靶点。转移性乳腺癌细胞通过多种机制获得其侵袭性特征，包括增强生存、增殖、致瘤性和与运动相关的细胞途径。显然，天然产物衍生的化合物长期以来一直被认为是抗癌药物的重要来源，其中一些已被证明通过抑制支持这种细胞侵袭性的关键分子特征而具有有前景的抗转移活性。本综述提供了乳腺癌的基本细节、基于分子的转移见解，以及乳腺癌治疗方法中潜在化合物的作用和机制。由于癌细胞的侵袭和转移能力被视为癌症的标志，具有抗转移作用的化合物及其明确的分子药物作用可能有益于新药开发和治疗策略。
