Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, T-1218 MCN, 1161 21st Ave S., Nashville, TN, 37232-2650, USA.
Crit Care. 2018 May 2;22(1):115. doi: 10.1186/s13054-018-2047-4.
Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient.
ClinicalTrials.gov, NCT02871102. Registered on 12 August 2016.
急性呼吸窘迫综合征患者的最佳呼气末正压（PEEP）仍在积极研究中。大多数试验通过调整 PEEP 来优化单一的生理参数（如驱动压），同时保持其他呼吸机参数不变。然而，最佳 PEEP 可能取决于潮气量，在相同患者中，使用不同潮气量进行最佳 PEEP 试验可能导致不同的最佳 PEEP 设置。
ClinicalTrials.gov，NCT02871102。于 2016 年 8 月 12 日注册。
