病毒突变率的复杂性。
Complexities of Viral Mutation Rates.
机构信息
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
出版信息
J Virol. 2018 Jun 29;92(14). doi: 10.1128/JVI.01031-17. Print 2018 Jul 15.
Abstract
Many viruses evolve rapidly. This is due, in part, to their high mutation rates. Mutation rate estimates for over 25 viruses are currently available. Here, we review the population genetics of virus mutation rates. We specifically cover the topics of mutation rate estimation, the forces that drive the evolution of mutation rates, and how the optimal mutation rate can be context-dependent.
摘要
许多病毒进化迅速。这部分归因于它们的高突变率。目前已有超过 25 种病毒的突变率估计值。在这里，我们回顾了病毒突变率的群体遗传学。我们特别涵盖了突变率估计、驱动突变率进化的力量以及最佳突变率如何具有上下文依赖性等主题。
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