Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1Youyi Road, Chongqing, 400016, China.
Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, 100871, China.
Neurol Sci. 2018 Jul;39(7):1151-1159. doi: 10.1007/s10072-018-3426-y. Epub 2018 May 2.
Dialysis encephalopathy (DE) is a progressive, fatal disease with a high mortality rate. Understanding the causes of this disease and the efforts to prevent and treat it would help improve the prognosis and quality of life of affected patients. This paper reviews the etiology, clinical features, methods of examining accessory features, diagnosis, treatment, and prevention of DE. We found that DE is likely to be related to aluminum poisoning. The clinical manifestations of DE include language disorders, mental and behavioral disorders, cognitive decline, and movement disorders. Electroencephalogram (EEG) findings mainly consist of an abundance of low waves, intermittent bilateral synchronous high-amplitude spikes, and ridge waves. Assessing the clinical features and obtaining an EEG are of great value in diagnosis, and DE is treated by both reducing aluminum intake and increasing aluminum excretion. Deferoxamine (DFO) is an effective treatment for DE.
透析脑病（DE）是一种进行性、致命性疾病，死亡率较高。了解该疾病的病因以及预防和治疗方法，有助于改善患者的预后和生活质量。本文就 DE 的病因、临床特点、辅助检查方法、诊断、治疗和预防进行综述。我们发现 DE 可能与铝中毒有关。DE 的临床表现包括语言障碍、精神和行为障碍、认知能力下降和运动障碍。脑电图（EEG）表现主要为低波幅增多、间歇性双侧同步高波幅棘波和尖波。评估临床特点和获取 EEG 对诊断具有重要价值，DE 的治疗方法是减少铝的摄入和增加铝的排泄。去铁胺（DFO）是治疗 DE 的有效药物。
