Ma Rui, Yang Kefeng, Chen Cheng, Mao Xuanxia, Shen Xiuhua, Jiang Linlei, Ouyang Fengxiu, Tian Ying, Zhang Jun, Kahe Ka
Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Nutrition, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Expo Sci Environ Epidemiol. 2021 Mar;31(2):248-256. doi: 10.1038/s41370-021-00294-9. Epub 2021 Feb 17.
Aluminum (Al) is a well-established neurotoxicant. However, little is known about its effects on the neurodevelopment of infants.
To examine early-life exposure to Al in relation to neurodevelopment in healthy infants.
Nail Al concentrations were measured among 747 newborn babies within 6 months of delivery in the Shanghai Birth Cohort. Neurodevelopment was assessed using Ages and stages questionnaire (third edition, ASQ-3) at ages 6 and 12 months. General linear regression models were performed to estimate the associations between Al concentrations and ASQ-3 scores.
After adjustment for potential confounders, early-life exposure to Al was not associated with any neurodevelopmental performance at age 6 months. However, Al level was associated with an increased risk of having a low fine motor score (quartile 4 vs. quartile 1, mean difference (MD): -1.63; 95% confidence interval (CI): -3.22, -0.05; P-trend < 0.01) at 12 months. No association was found for communication, gross motor, problem-solving, or personal-social score at 12 months.
Early-life exposure to Al may be associated with poor fine motor skills in a dose-response manner among apparently healthy infants at age 12 months.
铝是一种公认的神经毒素。然而，关于其对婴儿神经发育的影响却知之甚少。
研究健康婴儿早期接触铝与神经发育的关系。
在上海出生队列中，对747名出生后6个月内的新生儿测量指甲中的铝浓度。在6个月和12个月时，使用年龄与发育进程问卷（第三版，ASQ-3）评估神经发育情况。采用一般线性回归模型估计铝浓度与ASQ-3评分之间的关联。
在调整潜在混杂因素后，早期接触铝与6个月时的任何神经发育表现均无关联。然而，铝水平与12个月时精细动作得分低的风险增加相关（四分位数4与四分位数1相比。平均差（MD）：-1.63；95%置信区间（CI）：-3.22，-0.05；P趋势<0.01）。在12个月时，未发现沟通、大运动、问题解决或个人社交得分有相关性。
在12个月大的明显健康婴儿中，早期接触铝可能以剂量反应方式与精细动作技能差有关。
