Saito Y, Nakao K, Sugawara A, Nishimura K, Morii N, Yamada T, Itoh H, Shiono S, Mukoyama M, Arai H
Department of Medicine, Kyoto University School of Medicine, Japan.
Am Heart J. 1988 Oct;116(4):1052-7. doi: 10.1016/0002-8703(88)90159-7.
The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 +/- 19.2 pg/ml to 107.6 +/- 23.7 pg/ml (p less than 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 +/- 16.5 pg to 192.8 +/- 30.7 pg/ml (p less than 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p less than 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.
对9名原发性高血压患者进行了两项仰卧位自行车测力计运动试验，测量了他们血浆中心房利钠多肽（ANP）的浓度。在低强度运动（最大心率的50%）期间，血浆ANP浓度从97.0±19.2 pg/ml显著增加到107.6±23.7 pg/ml（p<0.05），在高强度运动（最大心率的75%）期间，从96.2±16.5 pg增加到192.8±30.7 pg/ml（p<0.01）。在高强度运动期间，血浆肾上腺素和去甲肾上腺素浓度显著增加。血浆ANP浓度与收缩压显著相关（r = 0.51；p<0.05）。与血压正常的受试者相比，原发性高血压患者在运动期间血浆ANP浓度和收缩压的绝对增加幅度更大。这些结果表明，运动可根据原发性高血压患者运动强度刺激ANP分泌，并且收缩压升高幅度更大导致的心房压力更大升高可能参与了原发性高血压患者ANP的过度分泌。
