组成型激活突变 mTOR 促进色素性视网膜炎小鼠的锥体存活。
Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice.
机构信息
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Dean McGee Eye Institute, Oklahoma City, OK, USA.
出版信息
Adv Exp Med Biol. 2018;1074:491-497. doi: 10.1007/978-3-319-75402-4_61.
Abstract
Studies form our laboratory and others show that the oncogenic tyrosine kinase and serine threonine kinase signaling pathways are essential for cone photoreceptor survival. These pathways are downregulated in mouse models of retinal degenerative diseases. In the present study, we found that activation mutants of mTOR delayed the death of cones in a mouse model of retinal degeneration. These studies suggest that oncogenic protein kinases may be useful as therapeutic agents to treat retinal degenerations that affect cones.
摘要
我们实验室和其他实验室的研究表明，致癌酪氨酸激酶和丝氨酸苏氨酸激酶信号通路对于视锥细胞的存活至关重要。这些通路在视网膜退行性疾病的小鼠模型中被下调。在本研究中，我们发现 mTOR 的激活突变体可延迟视网膜变性小鼠模型中视锥细胞的死亡。这些研究表明，致癌蛋白激酶可能可作为治疗影响视锥细胞的视网膜变性的治疗剂。
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