Goldberg Scott A, Dworkis Daniel A, Liao Vincent T, Eyre Andrew J, Albert Jack, Fawcett Meghan M, Narovec Conor M, DiClemente James, Weiner Scott G
Prehosp Emerg Care. 2018 Nov-Dec;22(6):788-794. doi: 10.1080/10903127.2018.1461284. Epub 2018 May 3.
Pre-stationing naloxone, a competitive antagonist that can reverse the effects of opioid overdose, in public spaces may expedite antidote delivery. Our study aimed to determine the feasibility of bystander-assisted overdose treatment using pre-stationed naloxone.
Convenience sample of bystanders in Cambridge, Massachusetts in April 2017. Subjects assisted a simulated patient described as unconscious. Subjects interacted with simulated EMS dispatch to locate a nearby box, unlock it, and administer naloxone.
Fifty participants completed the simulation. Median time from simulated ambulance dispatch to naloxone administration was 189 seconds, and from arrival at patient side to administration 61 seconds. All but one participant (98.0%) correctly administered naloxone. Subjects' comfort with administration and willingness to provide medical care increased from before to after the trial. Comfort in administering naloxone varied significantly with level of previous training prior to, but not following, study participation.
Bystanders are willing and able to access pre-stationed naloxone and administer it to a simulated patient in a public space. Public access naloxone stations may be a useful tool to reduce time to naloxone administration, particularly in areas where opioid overdoses are clustered.
预先在公共场所放置纳洛酮（一种可逆转阿片类药物过量效应的竞争性拮抗剂）可能会加快解毒剂的递送。我们的研究旨在确定使用预先放置的纳洛酮进行旁观者辅助过量治疗的可行性。
2017年4月在马萨诸塞州剑桥市对旁观者进行便利抽样。受试者协助一名被描述为昏迷的模拟患者。受试者与模拟的紧急医疗服务调度人员互动，以找到附近的箱子，打开它，并给予纳洛酮。
50名参与者完成了模拟。从模拟救护车调度到给予纳洛酮的中位时间为189秒，从到达患者身边到给予纳洛酮的时间为61秒。除一名参与者外（98.0%），所有参与者均正确给予了纳洛酮。受试者对给药的舒适度和提供医疗护理的意愿在试验前后有所增加。在参与研究之前，给予纳洛酮的舒适度因先前培训水平而异，但在参与研究之后则没有差异。
旁观者愿意且能够获取预先放置的纳洛酮并将其给予公共场所的模拟患者。公共获取纳洛酮站可能是减少给予纳洛酮时间的有用工具，特别是在阿片类药物过量聚集的地区。
