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精子库的回顾性研究:乌拉圭的经验

A retrospective study on sperm banking: a Uruguayan experience.

作者信息

Ordoqui Rosina, Barrera Natalibeth, Montes José María, Canepa Mariel, Bonelli Carla, Surka Carolina, Torrens Andrea, Cantú Lidia, Plessis Stefan S du

机构信息

Fertilab Laboratorio de Análisis Clínicos, Laboratorio de Andrología, Montevideo, Uruguay.

Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

出版信息

JBRA Assist Reprod. 2018 Jun 1;22(2):82-88. doi: 10.5935/1518-0557.20180037.

DOI:10.5935/1518-0557.20180037
PMID:29727140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5982550/
Abstract

OBJECTIVE

The purpose of this study was to investigate the status of homologous sperm banking in Uruguay.

METHODS

A retrospective investigation was performed on data collected between 2013 and 2015. Reasons for sperm banking, patient age, pre-freeze and post-thaw semen parameters, and recovery rates were analyzed.

RESULTS

623 samples were cryobanked between 2013 and 2015. Only 324 samples were considered for analysis after selection based on inclusion criteria. In most cases the samples were stored because the patients were undergoing assisted reproductive technology (ART) treatment (n=190; 58,64%) or for oncological reasons (n=113; 34,88%). The median age of bankers was 34 years. In the cancer group, 61.95% (n=70) of the subjects had been diagnosed with testicular cancer. Medians of semen parameters for both groups were above the lower reference limits dictated by the . In fresh samples, a significant difference was observed in progressive motility (47% vs. 56%) between ART and oncological patients. After thawing, total motility (27% vs. 32%), progressive motility (19% vs. 22%), and vitality (48% vs. 56%) differed significantly between ART and oncological bankers.

CONCLUSION

Semen banking has been performed successfully in Uruguay and outcomes are on par with international standards. Surprisingly, the semen parameters of the cancer group were nearly normal.

摘要

目的

本研究旨在调查乌拉圭同源精子库的现状。

方法

对2013年至2015年期间收集的数据进行回顾性调查。分析了精子库保存的原因、患者年龄、冻融前后的精液参数以及回收率。

结果

2013年至2015年期间共冷冻保存了623份样本。根据纳入标准筛选后,仅324份样本被纳入分析。在大多数情况下,样本被保存是因为患者正在接受辅助生殖技术(ART)治疗(n = 190;58.64%)或出于肿瘤学原因(n = 113;34.88%)。精子库保存者的中位年龄为34岁。在癌症组中,61.95%(n = 70)的受试者被诊断患有睾丸癌。两组的精液参数中位数均高于[具体标准]规定的下限参考值。在新鲜样本中,ART患者和肿瘤患者之间的前向运动率存在显著差异(47%对56%)。解冻后,ART患者和肿瘤患者在总运动率(27%对32%)、前向运动率(19%对22%)和活力(48%对56%)方面存在显著差异。

结论

乌拉圭已成功开展精液库保存工作,结果与国际标准相当。令人惊讶的是,癌症组的精液参数几乎正常。

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本文引用的文献

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Fertility preservation in males with cancer: 16-year monocentric experience of sperm banking and post-thaw reproductive outcomes.癌症男性的生育力保存:精子库的16年单中心经验及解冻后的生殖结局
Ther Adv Med Oncol. 2016 Nov;8(6):412-420. doi: 10.1177/1758834016665078. Epub 2016 Aug 30.
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