Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Andrology Lab, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Investig Clin Urol. 2023 Sep;64(5):489-494. doi: 10.4111/icu.20220402.
We compared semen quality and sperm DNA fragmentation in cancer patients who underwent sperm banking and controls who underwent sperm cryopreservation for assisted reproductive technology (ART).
A total of 132 men, 65 cancer patients and 67 controls, were prospectively enrolled and performed sperm cryopreservation for fertility preservation from May 2019 to February 2021. Sperm quality was determined by measuring semen volume, sperm concentration, sperm motility, and sperm DNA fragmentation index (DFI). Sperm quality and sperm DFI were compared in cancer patients and controls.
The major cancers of the 65 cancer patients were leukemia (26.2%), testicular cancer (23.1%), and lymphoma (20.0%). Sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls. Sperm DFI was significantly higher in cancer patients than in controls (24.32%±15.69% vs. 19.11%±11.63%; p=0.033). After excluding 8 cancer patients who received chemotherapy before sperm banking, sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls, but there was no significant difference in sperm DFI for cancer patients and controls (23.14%±12.79% vs. 19.11%±11.63%; p=0.069).
Sperm quality was lower in cancer patients than in controls. There was no difference in the sperm DFI of cancer patients prior to chemotherapy and men presenting for sperm cryopreservation for ART. We recommend that all men who are planning cancer therapy should be offered sperm banking prior to gonadotoxic chemotherapy as a standard of fertility preservation.
我们比较了接受精子库保存的癌症患者和接受辅助生殖技术（ART）精子冷冻保存的对照组的精液质量和精子 DNA 碎片化。
共前瞻性纳入 132 名男性，65 例癌症患者和 67 例对照组，于 2019 年 5 月至 2021 年 2 月期间进行精子冷冻保存以进行生育力保存。通过测量精液量、精子浓度、精子活力和精子 DNA 碎片化指数（DFI）来确定精子质量。比较了癌症患者和对照组的精子质量和精子 DFI。
65 例癌症患者的主要癌症为白血病（26.2%）、睾丸癌（23.1%）和淋巴瘤（20.0%）。与对照组相比，癌症患者的精子浓度、总精子活力和前向精子活力明显较低。与对照组相比，癌症患者的精子 DFI 明显较高（24.32%±15.69%比 19.11%±11.63%；p=0.033）。排除 8 例在精子库保存前接受化疗的癌症患者后，与对照组相比，癌症患者的精子浓度、总精子活力和前向精子活力明显较低，但癌症患者和对照组的精子 DFI 无显著差异（23.14%±12.79%比 19.11%±11.63%；p=0.069）。
癌症患者的精子质量低于对照组。化疗前癌症患者和接受 ART 精子冷冻保存的男性的精子 DFI 无差异。我们建议所有计划进行癌症治疗的男性在接受性腺毒性化疗前应进行精子库保存，作为生育力保存的标准。
