膦甲酸钠乳膏、阿昔洛韦乳膏和阿昔洛韦软膏在实验性皮肤单纯疱疹病毒1型感染局部治疗中的比较。
Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection.
作者信息
Spruance S L, Freeman D J, Sheth N V
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):196-8. doi: 10.1128/AAC.30.1.196.
Abstract
Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea pig skin 7- to 10-fold faster than did ACV in ointment.
摘要
在1型单纯疱疹病毒感染的豚鼠背部皮肤模型中，对局部用膦甲酸钠（PFA）和阿昔洛韦（ACV）进行了比较。疗效的相对顺序为PFA乳膏＞ACV乳膏＞ACV软膏。体外研究表明，与软膏中的ACV相比，乳膏载体中配制的PFA和ACV穿透豚鼠皮肤的速度快7至10倍。
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本文引用的文献
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Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol.用聚乙二醇中的局部阿昔洛韦治疗唇疱疹。
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Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir.早期由患者自行使用外用10%阿昔洛韦治疗唇疱疹。
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Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection.阿昔洛韦在不同载体中对豚鼠皮肤的渗透及其与实验性皮肤单纯疱疹病毒感染局部治疗疗效的相关性
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Successful treatment of herpes labialis with topical acyclovir.外用阿昔洛韦成功治疗唇疱疹。
Br Med J (Clin Res Ed). 1983 May 28;286(6379):1699-701. doi: 10.1136/bmj.286.6379.1699.
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Acyclovir in the management of herpes labialis.阿昔洛韦用于唇疱疹的治疗。
J Antimicrob Chemother. 1983 Sep;12 Suppl B:95-103. doi: 10.1093/jac/12.suppl_b.95.
7
Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections.复发性口面部单纯疱疹感染患者的局部阿昔洛韦治疗
J Antimicrob Chemother. 1983 Sep;12 Suppl B:89-93. doi: 10.1093/jac/12.suppl_b.89.
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Topical acyclovir in the treatment of genital herpes: a comparison with systemic therapy.局部用阿昔洛韦治疗生殖器疱疹：与全身治疗的比较。
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Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.在细胞培养中对胸腺嘧啶核苷逆转核苷类似物抗疱疹活性的动力学分析。
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Intracellular pools of thymidine reduce the antiviral action of acyclovir.
Intervirology. 1983;20(1):48-51. doi: 10.1159/000149373.
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