Schwabe M, Wagner L, Prischl F, Pinter G, Schwarzmeier J D
1. Medizinische Universitätsklinik, Wien, Osterreich.
Onkologie. 1988 Aug;11(4):155-8. doi: 10.1159/000216514.
Lymphoblastoid cells were subjected to Western Blot analysis for detection of Interferon-alpha-binding proteins. JOK-1 cells--a human hairy cell leukemia line--revealed three proteins with apparent molecular weights of 120, 100 and 32 kD, respectively. Down-regulation of the receptor was observed. A differential binding pattern of two proteins (100 and 85 kD) was observed in T-CLL, whereas no signal detection was achieved in B-CLL. Mononuclear cells from 6 patients with hairy cell leukemia and 6 patients with CLL were found to differ significantly in terms of nucleic acid precursor incorporation.
