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评估p16和p27在口腔上皮发育异常和口腔鳞状细胞癌中的表达：一种癌变的诊断标志物。

Evaluating the expression of p16 and p27 in oral epithelial dysplasias and oral squamous cell carcinoma: A diagnostic marker for carcinogenesis.

作者信息

Thambiah Lalita Jayaram, Bindushree R V, Anjum Afshan, Pugazhendi Satish Kumaran, Babu Lokesh, Nair Renju Prem

机构信息

Department of Oral Maxillofacial Pathology and Microbiology, MR Ambedkar Dental College, Bangalore, Karnataka, India.

Department of Oral Maxillofacial Surgery, MR Ambedkar Dental College, Bangalore, Karnataka, India.

出版信息

J Oral Maxillofac Pathol. 2018 Jan-Apr;22(1):59-64. doi: 10.4103/jomfp.JOMFP_92_17.

DOI:10.4103/jomfp.JOMFP_92_17
PMID:29731558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917543/
Abstract

OBJECTIVE

Immunohistochemical evaluation of the degree of expression of p16 and p27 in oral epithelial dysplasia and different histological grades oral squamous carcinoma.

MATERIALS AND METHODS

The study consisted of 5 cases of oral squamous cell carcinoma (OSCC), 5 cases of low-risk potentially malignant disorders (PMDs), 5 cases of high-risk PMDs and 5 cases of normal epithelium. Five micrometer thickness sections on a positively charged slide were subjected to immunohistochemical staining for the localization of p16 and p27. The expression of p16 and p27 was assessed in 10 random high-power fields (×40). Staining intensity was graded, and the data were subjected to statistical analysis.

RESULTS AND CONCLUSION

OSCC and high-grade PMDs showed decreased intensity for both p16and P27. In our study, we concluded that p16 and p27 could be used as a diagnostic marker for predicting carcinogenesis in epithelial dysplasia.

摘要

目的

免疫组织化学评估p16和p27在口腔上皮发育异常及不同组织学分级的口腔鳞状细胞癌中的表达程度。

材料与方法

本研究包括5例口腔鳞状细胞癌（OSCC）、5例低风险潜在恶性疾病（PMD）、5例高风险PMD和5例正常上皮组织。将带正电荷载玻片上5微米厚的切片进行免疫组织化学染色，以定位p16和p27。在10个随机高倍视野（×40）中评估p16和p27的表达。对染色强度进行分级，并对数据进行统计分析。

结果与结论

OSCC和高级别PMD中p16和p27的强度均降低。在我们的研究中，我们得出结论，p16和p27可作为预测上皮发育异常癌变的诊断标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/50d6f7abdac6/JOMFP-22-59-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/363213b9d6cf/JOMFP-22-59-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/d8fc2952abe8/JOMFP-22-59-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/31372c9c620e/JOMFP-22-59-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/34876f9afa4c/JOMFP-22-59-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/257024f27d5a/JOMFP-22-59-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/994df4fb3d12/JOMFP-22-59-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/865133d70fa8/JOMFP-22-59-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/67ae986056ff/JOMFP-22-59-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/ddfed0c1e6d0/JOMFP-22-59-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/50d6f7abdac6/JOMFP-22-59-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/363213b9d6cf/JOMFP-22-59-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/d8fc2952abe8/JOMFP-22-59-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/31372c9c620e/JOMFP-22-59-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/34876f9afa4c/JOMFP-22-59-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/257024f27d5a/JOMFP-22-59-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/994df4fb3d12/JOMFP-22-59-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/865133d70fa8/JOMFP-22-59-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/67ae986056ff/JOMFP-22-59-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/ddfed0c1e6d0/JOMFP-22-59-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224e/5917543/50d6f7abdac6/JOMFP-22-59-g013.jpg

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