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细胞角蛋白19作为生物标志物在口腔鳞状细胞癌早期检测中的表达

Expression of CK 19 as a biomarker in early detection of oral squamous cell carcinoma.

作者信息

Rajeswari Parvathy, Janardhanan Mahija, Suresh Rakesh, Savithri Vindhya, Aravind Thara, Raveendran Greeshma C

机构信息

Department of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Department of Biostatistics, Amrita School of Medicine, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

出版信息

J Oral Maxillofac Pathol. 2020 Sep-Dec;24(3):523-529. doi: 10.4103/jomfp.JOMFP_302_19. Epub 2021 Jan 9.

DOI:10.4103/jomfp.JOMFP_302_19
PMID:33967491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083407/
Abstract

BACKGROUND

Increased mortality in oral squamous cell carcinoma (OSCC) had been attributed to delay in diagnosis. Lack of a specific marker to assess the malignant potential of premalignant lesions is thought to be one of the reasons for late detection. Expression of Cytokeratin 19, which is widely used as an odontogenic epithelial marker had been reported in OSCC. Downregulation of CK 19 expression plays an important role in terminal differentiation of superficial squamous cell and increased expression in various epithelial malignancies has been suggested to be an indicator of malignant change.

AIMS AND OBJECTIVES

To assess the role of CK19 as a potential marker in predicting malignant transformation in oral precancerous lesions and as a prognostic marker in OSCC.

MATERIALS AND METHODS

Study population consisted of ten samples each of normal oral mucosa, epithelial hyperplasia, varying grades of both oral epithelial dysplasias and OSCC. The tissue sections were subjected to immunohistochemical staining for the marker cytokeratin 19.

RESULTS

An increased expression of CK19 was noted in oral epithelial hyperplasia, severe dysplasia and in superficial epithelium at the invading front in OSCC. In mild and moderate dysplasias, CK19 expression was lower than the normal mucosa. In oral squamous cell carcinoma, the expression of CK19 was restricted to either a few islands or a few cells within the islands, resulting in a lesser expression than the normal epithelium. The malignant epithelial islands in the superficial connective tissue stroma were showing greater expression than the deeper islands. The epithelial cells associated with formation of keratin pearls were found to be showing more expression than those with infrequent keratin pearls.

CONCLUSION

The study suggests that malignant transformation of epithelium can be predicted based on the increased expression of CK19. But it should be done with caution as a similar increased expression may also be noticed in presence of inflammation.

摘要

背景

口腔鳞状细胞癌（OSCC）死亡率的增加归因于诊断延迟。缺乏评估癌前病变恶性潜能的特异性标志物被认为是晚期检测的原因之一。细胞角蛋白19作为一种广泛应用的牙源性上皮标志物，其表达已在OSCC中被报道。CK 19表达的下调在浅表鳞状细胞的终末分化中起重要作用，而在各种上皮恶性肿瘤中其表达增加被认为是恶性变化的一个指标。

目的

评估CK19作为预测口腔癌前病变恶性转化的潜在标志物以及作为OSCC预后标志物的作用。

材料与方法

研究人群包括正常口腔黏膜、上皮增生、不同等级的口腔上皮发育异常和OSCC的各10个样本。对组织切片进行细胞角蛋白19标志物的免疫组织化学染色。

结果

在口腔上皮增生、重度发育异常以及OSCC侵袭前沿的浅表上皮中，观察到CK19表达增加。在轻度和中度发育异常中，CK19表达低于正常黏膜。在口腔鳞状细胞癌中，CK19的表达局限于少数细胞岛或细胞岛内的少数细胞，导致其表达低于正常上皮。浅表结缔组织基质中的恶性上皮岛比深部的岛显示出更高的表达。发现与角质珠形成相关的上皮细胞比角质珠少见的细胞显示出更多的表达。

结论

该研究表明，基于CK19表达增加可预测上皮的恶性转化。但应谨慎进行，因为在炎症存在时也可能观察到类似的表达增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/c2fe318e9026/JOMFP-24-523-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/818f9dffdafb/JOMFP-24-523-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/c2fe318e9026/JOMFP-24-523-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/680557ae362b/JOMFP-24-523-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/bdefe4e7455c/JOMFP-24-523-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/bf049ac2e15f/JOMFP-24-523-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/dfddbf1ac70c/JOMFP-24-523-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/1781e99ffb71/JOMFP-24-523-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/14e4265c5d92/JOMFP-24-523-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/be7e83dd813a/JOMFP-24-523-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/f84754abdb27/JOMFP-24-523-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/0c7b85ff37de/JOMFP-24-523-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/818f9dffdafb/JOMFP-24-523-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537e/8083407/c2fe318e9026/JOMFP-24-523-g012.jpg

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