Verloh Niklas, Utpatel Kirsten, Haimerl Michael, Zeman Florian, Fellner Claudia, Dahlke Marc, Renner Philipp, Seyfried Timo, Müller Martina, Stroszczynski Christian, Evert Matthias, Wiggermann Philipp
Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
Department of Pathology, University Regensburg, Regensburg, Germany.
Oncotarget. 2018 Apr 13;9(28):20112-20118. doi: 10.18632/oncotarget.24981.
The aim of this study was to determine the diagnostic value of diffusion-weighted MRI of the liver at 3T to classify liver fibrosis/cirrhosis.
62 patients who underwent both histopathological examination and diffusion-weighted imaging of the liver via 3T MRI within a period of 3 months were included in the study. The Ishak score (1-6) was used to determine the degree of fibrosis: No liver fibrosis (NLF; Ishak 0, n = 16), mild liver fibrosis (MLF; Ishak 1-2, n = 23), advanced liver fibrosis (ALF; Ishak 3-5, n = 12), and liver cirrhosis (LC; Ishak 6, n = 11).
The corresponding ADC values for the individual patient groups were as follows: NLF: 1123 (SD 95.8); MLF: 1032 (SD 77.6); ALF: 962 (SD 68.8); LC: 1015 (SD 60.2) mm2/s. There is a significant difference between NLF and MLF (p = 0.004) and between MLF and ALF (p = 0.022). A significant difference between patients with ALF and LC (p = 0.117) could not be found.
Liver fibrosis/cirrhosis lowers the ADC values of the liver parenchyma in 3T MRI. However, the degree of fibrosis can only be conditionally determined on the basis of ADC values.
本研究旨在确定3T磁共振成像（MRI）肝脏扩散加权成像对肝纤维化/肝硬化进行分类的诊断价值。
本研究纳入62例在3个月内同时接受肝脏组织病理学检查和3T MRI肝脏扩散加权成像的患者。采用Ishak评分（1 - 6分）确定纤维化程度：无肝纤维化（NLF；Ishak 0分，n = 16）、轻度肝纤维化（MLF；Ishak 1 - 2分，n = 23）、重度肝纤维化（ALF；Ishak 3 - 5分，n = 12）和肝硬化（LC；Ishak 6分，n = 11）。
各患者组对应的表观扩散系数（ADC）值如下：NLF：1123（标准差95.8）；MLF：1032（标准差77.6）；ALF：962（标准差68.8）；LC：1015（标准差60.2）mm²/s。NLF与MLF之间（p = 0.004）以及MLF与ALF之间（p = 0.022）存在显著差异。未发现ALF与LC患者之间存在显著差异（p = 0.117）。
肝纤维化/肝硬化会降低3T MRI中肝实质的ADC值。然而，仅根据ADC值只能有条件地确定纤维化程度。
